Notre Dame Study of Health & Well-being

描述（由申请人提供）：该提案是对圣母大学健康与福祉研究（NDHWB; R 01 AG 023571）的竞争性更新，以支持对生活压力在成年人一生中促进身心健康的无数途径的调查，以及可能保护这些人免受逆境不良影响的弹性机制。现有的数据集在压力测量的丰富性方面是无与伦比的，收集了跨越5年的多个时间点，包括5次年度问卷评估和3次56天的数据爆发（第1年，第3年和第5年;中年队列中的两次）。这些数据使我们能够研究多种形式的逆境，它们的共同和独特的联系，以及随后的健康和福祉指标。根据目前的建议，我们通过收集额外的纵向数据（将研究扩展到10年）来扩大研究范围，在晚年队列（7岁和9岁）中增加2个额外的数据爆发，在中年队列（6岁，8岁和10岁）中增加3个数据爆发。我们通过增加一个年轻的成年人队列（18 - 40岁）来扩展研究，通过5个年度问卷和3个数据突发（第1年，第3年和第5年）来评估他们，以更好地了解这些因素如何在成年后发展和维持。最后，我们建议在一组受试者（每组50人）中增加两次为期10天的皮质醇评估（每天收集3次），以捕获对压力的生理反应。扩展项目的总体目标是双重的：全面，准确地详细说明生活压力的类型和质量，可能会引发可能导致疾病和疾病的感知，情感和生物反应的级联，并检查抵御它们的弹性资源。

DESCRIPTION (provided by applicant): This proposal is for a competitive renewal of the Notre Dame Study of Health and Well-being (NDHWB; R01 AG023571) to support an investigation of the myriad pathways through which life stress contributes to the physical and mental health across the adult lifespan, and of the resilience mechanisms that may protect those individuals from the ill-effects of exposure to adversity. The existing data set is unparalleled in the richness of stress measurement, collected over multiple time points spanning 5 years and including 5 annual questionnaire assessments and three 56-day data bursts (Years 1, 3, & 5; two in the midlife cohort). These data allow us to examine multiple forms of adversity, their common and distinctive linkages, with subsequent indicators of health and well-being. With the present proposal, we broaden the study by collecting additional longitudinal data (expanding the study to 10 years), adding 2 additional data bursts to the later life cohort (Years 7 & 9) and 3 bursts in the mid-life cohort (Years 6, 8, & 10). We extend the study by adding a young adult cohort (ages 18 - 40), assessing them with 5 annual questionnaires and 3 data bursts (years 1, 3, & 5) to better understand how these factors are developed and maintained in adulthood. Finally, we propose to add two 10-day bursts of cortisol assessments (collected 3 X day) on a subset of subjects (50 per cohort) to capture physiological responses to stress. The overarching goal of the expanded project is twofold: to comprehensively and precisely detail the types and qualities of life stress that may initiate the cascade of perceptual, emotional, and biological responses that can lead to disorder and disease, and to examine resilience resources that protect against them.