Investigating the relationship between Depression, Anxiety and Nausea and Vomiting during Pregnancy: Causation or shared liability?

最近的研究表明，在怀孕期间经历严重恶心和呕吐（NVP）的女性在怀孕前有更高的焦虑和抑郁率，这重新提出了NVP可能有心理因素的早期假设。我们假设焦虑和抑郁在NVP中不起因果作用，相反，这种关系是由于影响这两种特征的遗传效应的共同风险。我们将使用遗传学和流行病学方法来检验这一假设。

Recent studies showing women who experience severe Nausea and vomiting during pregnancy (NVP) have higher rates of Anxiety and Depression prior to pregnancy have revived earlier hypotheses that NVP may have a psychogenic component. We hypothesize that Anxiety and Depression do not play a causal role in NVP but rather, the relationship is due to shared risk from genetic effects that influence both traits. We will test this hypothesis using genetic and epidemiological approaches.