Center for Research in Diagnostics and Discovery

描述(由申请人提供)：准确的诊断对适当的医疗至关重要。这常常被缺乏或限制提供信息的诊断分析和工具所混淆。在特定社区或国家很少发现的感染性病原体通常不会进行筛查，因为多项单一诊断化验成本高昂，而且对最有可能的病原体进行检测被认为是有必要的。然而，越来越清楚的是，随着传染病病原体出现在新的地理区域和环境中，医疗和公共卫生界必须改进和更新他们所使用的方法。诊断和发现研究中心的目标是开发、验证和实施多重平台和预测策略，以促进对新病原体的检测，确定影响敏感性的宿主因素 预测疾病和预测药物和疫苗的有效性。我们将汇聚分子生物学、系统生物学、遗传学和生物工程等领域的研究人员。我们还将召集公共卫生界成员和保护生物学家。诊断和发现研究中心的研究人员将共同推进知识和平台，以检测以前未确定的已知流行病原因的病原体，或通过开发和利用可以快速重定向到任何类型病原体的系统来选择病原体。 相关性：诊断化验是医疗的主要要点。医学界目前使用的检测方法不能提供快速诊断和准确治疗的关键--效率和多重化。诊断和发现研究中心将应用和开发现代最先进的技术，以创造能够为医学界提供信息的新工具。

DESCRIPTION (provided by applicant): Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type. RELEVANCE: Diagnostic assays are the primary point for medical treatment. The assays used today by the medical community do not provide the efficiency and multiplexing that are key to rapid diagnosis and accurate treatment. The Center for Research in Diagnostics and Discovery will apply and develop modern state-of-the-art technologies for the creation of new tools that can be informative to the medical community.