DATA MANGEMENT AND STATISTICS CORE

数据库管理和统计核心(DMS)将自1989年哥伦比亚ADRC成立以来一直存在于临床核心内的中央数据管理和生物统计资源和功能正规化。DMS核心于五年前正式成立，由两个组成部分和协调良好的部门组成，一个负责生物统计/流行病学，另一个负责数据 管理职能。数据管理构成部分将继续管理一个大型、高度结构化的关系数据库，目前包含3 800多名受试者的所有临床评价和神经病理检查数据，包括自目前的UDS开始以来收集的所有NACC UDS数据。在拟议的供资期间，数据库管理部分将继续以电子方式提交初始和后续UDS信息包，格式为国家阿尔茨海默病 该中心将成为本申请所述项目的数据、流行病学和统计资源的核心资源，并将成为与外部调查人员和国家协调中心发起的研究项目之间经批准的合作的核心资源。 统计和流行病学部分将与每个项目的调查人员密切合作，设计和实施统计分析，并协助编写和审查手稿以供出版。 统计和流行病学部分还将限于作为国家反腐败委员会协作项目的资源，并将与外部和内部调查人员一起参与设计和分析协作特别研究工作。DMS核心的两个组成部分的工作人员将被限制参加每周与其他核心和项目的领导人的预定会议，以审查和讨论所有与数据相关的问题，包括：1)招聘和后续；2)协调临床和 神经病理核心；4)项目和合作者对数据、科学规划和数据分析的需求。

The Database Management and Statistics Core (DMS) formalizes central data management and biostatistical resources and functions that have existed within the Clinical Core since the inception of the Columbia ADRC in 1989. The DMS Core, which was formally established five years ago, is composed of two component and well-coordinated arms, one for biostatistical/epidemiological and the other for data management functions. The Data Management Component will continue to manage a large, highly structured relational database currently containing all clinical evaluation and neuropathological examination data on a large cohort of over 3,800 subjects, including all NACC UDS data collected since the inception of the current UDS . In the proposed funding period the Database Management Component will continue to electronically submit initial and followup UDS packets in the format required by the National Alzheimer's Coordinafing Center (NACC) in a fimely manner, and will serve as a central resource for data, epidemiological and statistical resources to the projects described in this application, as well as to approved collaborations with external investigators and NACC-initiated research projects. The Statistics and Epidemiology Component will work closely with the investigators of each project to design and implement statistical analyses, and to assist in the preparation and review of manuscripts for publication. The Statistics and Epidemiology Component will also confinue to be a resource for collaborative NACC projects and will participate in the design and analysis of collaborative ad hoc research efforts with external and internal investigators. Staff of both components ofthe DMS Core will confinue to participate in weekly, scheduled meetings with leaders of the other cores and projects to review and discuss all data-related issues, including: 1) recruitment and followup ; 2) coordination of data fiow between the clinical and neuropathological cores, and 4) the needs ofthe projects and collaborators for data, stafisfical planning and data analysis.