Biospecimen Repository - Division of Epidemiology, Statistics & Prevention Res.

Eunice Kennedy Shriver国家儿童健康与人类发展研究所（NICHD）的校内人口健康研究部（以下简称“司”）设立了一个内部委员会，即生物标本库访问和数据共享委员会（BRADSC），以监督存储库访问和数据共享计划。BRADS委员会将根据研究问题与当前研究的相关性来评估提交的生物标本提案；研究设计是否足以解决问题；进行新研究的原研究和材料的可行性和适当性；分析的适当性，包括分析物在长期储存下是稳定的证据；以及研究者进行类似研究的经验。

The Division of Intramural Population Health Research (hereafter, Division) of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has established an internal committee, the Biospecimen Repository Access and Data Sharing Committee (BRADSC), to oversee the repository access and data sharing program. The BRADS Committee will evaluate submitted proposals for biospecimens in terms of their relevance of the study question to current research; adequacy of the study design to address the question; feasibility and appropriateness of the source study and material for conducting the new study; appropriateness of the assay, including evidence that the analyte is stable under prolonged storage; and experience of the investigators in conducting similar studies. Access to Division resources is announced on the Division website. Announcements and current proposal guidelines are available under the Research link at http://despr.nichd.nih.gov, and interested researchers should consult the Division website for resources available, the most recent guidelines for proposal submission and evaluation, and cost schedules. Procedures may vary depending on the age and nature of the samples and original institutional review board (IRB) approval, although the general outline of the procedures should remain the same. Cost schedules may vary depending on the nature and complexity of the request. The specimens and ancillary data that are currently available under this program are those from the national Collaborative Perinatal Project (CPP, 1959-1966), the Norway-Alabama Fetal Growth Study (1986-1988), the Vaginal Infections and Prematurity Study (VIP, 1984-1989), the Calcium for Preeclampsia Prevention Trial (CPEP, 1992-1997), and the Longitudinal Study of Vaginal Flora (FLORA, 1999-2002). Other collections will be made available through this mechanism in a timely fashion. The approximate number of samples available for CPP: 198,389 serum, 36,215 cord bloods; Norway-Alabama Fetal Growth Study: 14,408 serum from Alabama, 11,817 serum from Norway; VIP: 30,067 serum; CPEP: 14,429 serum, 14,331 urine; and FLORA: 13,551 serum and vaginal washes, 3,569 periodontal swabs. Multiple aliquots are available for most samples. New collections are entered into the repository for recently completed (BioCycle, LIFE Study, ENDO Study, EAGeR Trail) and ongoing studies (NEXT Study, Diabetes and Women's Health, Fetal Growth, FAZST Trial).