Administrative Core/Leadership

加州大学弗雷斯诺分校将协调和执行招募，入组和数据/样本收集所有 与项目2和项目3相关的前瞻性研究队列。数据和样本收集的详细信息如下： 在各个项目协议中描述。分段自然史（PWNH）设计的研究队列 包括0-2岁、7-9岁、15-19岁和19-22奥尔兹四个年龄组。除出生数据外，所有研究 相关访视将在UCSF弗雷斯诺临床和转化研究中心进行。 0-2队列将包括220名孕妇，在第二个三个月期间收集产妇数据（< 22周）和出生时、出生后12个月和24个月收集的婴儿数据。孕妇将被招募 来自加州大学旧金山分校弗雷斯诺分校产科的多个围产期诊所。所有与分娩有关的 与这些诊所在加州大学旧金山分校弗雷斯诺附属医院进行。社区区域医疗中心 我们还将招募220名7-9岁的儿童，其中50%的儿童以前 被诊断为哮喘在CHAPS P20补助期间，300名儿童（100名哮喘儿童） 通过UCSF弗雷斯诺（泰纳先生）和弗雷斯诺之间的合作伙伴关系，我成功地参加了项目2 联合学区。类似的招募方法将适用于这一新的队列。数据/样本将 在两个时间点收集：入组（访视1）和入组后24个月（访视2）。 此外，100名青少年（15-19岁）之前入组了上述CHAPS P20项目 和100名之前入组FACES的年轻人（19-22岁）将重新联系并入组 单次数据/样本采集访视。

UCSF Fresno will coordinate and execute the recruitment, enrollment and data/sample collection for all prospective study cohorts associated with Projects 2 and 3. Details of the data and sample collection are described in the individual project protocols. Study cohorts of the piece-wise natural history (PWNH) design include four age groups, 0-2, 7-9, 15-19 and 19-22 year olds. With the exception of birth data, all study related visits will be conducted at the UCSF Fresno Center for Clinical and Translational Research. The 0-2 cohort will include 220 pregnant women, with maternal data collected during the second trimester (< 22 weeks) and infant data collected at birth, 12 and 24 months post-natal. Pregnant women will be recruited from multiple peri-natal clinics associated with the UCSF Fresno Obstetrics Department. All births associated with these clinics are performed at the UCSF Fresno-affiliated hospital. Community Regional Medical Center. We will also enroll 220 children for the 7-9 year old cohort, 50% of whom will have been previously diagnosed with asthma. During the CHAPS P20 grant period, 300 children (100 with asthma) were successfully enrolled in Project 2 through a partnership between UCSF Fresno (Mr. Tyner) and Fresno Unified School District. Similar recruitment methods will be applied for this new cohort. Data/samples will be collected at two time points: enrollment (visit 1) and 24 months post-enrollment (visit 2). In addition, 100 adolescents (15-19 years) previously enrolled in the above mentioned CHAPS P20 project and 100 young adults (19-22 years) previously enrolled in FACES will be re-contacted and enrolled for a single data/sample collection visit.