Social Integration, Daily Social Interaction, and Health Risk Pathways in Midlife

 描述（由申请人提供）：中年的社会融合、日常社会互动和健康风险途径--从实验啮齿动物模型到人类流行病学研究的一致证据表明，慢性人际压力可能与全身炎症增加有关，这是中年早期发病和死亡的风险因素。为了更好地理解这些影响并潜在地解决它们，我们需要更好地描述可能引发炎症反应的特定社会行为。在啮齿动物研究中，与同种动物的反复攻击性相互作用似乎会引起炎症的全身变化。同样，人类的实验室证据表明，冲突的婚姻互动，特别是那些伴随着敌对行为的互动，与循环炎症标志物浓度增加有关。然而，人们对类似的社会行为是否会在日常人际交往过程中引发炎症反应，以及这些影响在多大程度上可以解释慢性人际压力和炎症之间的联系知之甚少。作为正在进行的中年社会关系和健康风险途径调查的一部分（R 01 AG 041778），我们正在收集社会互动，情绪和炎症等变量的观察结果。该修订提案在这项母研究中增加了4项额外的测量;生活压力的访谈评估;糖皮质激素受体（GCR）敏感性的测量;尿儿茶酚胺;以及白细胞介素-6（IL-6）的每日血斑测量，这是一种炎症标志物。有了这些补充，这项研究为我们提供了一个独特的机会来研究可能在日常生活中引发炎症活动的社会过程，并探索一些可能解释这些影响的机制。了解日常社会互动如何解释慢性人际压力对健康的一些影响，对于在这一领域制定适当的治疗目标和干预方法至关重要。

 DESCRIPTION (provided by applicant): Social integration, daily social interaction, and health risk pathways in midlife a consistent body of evidence, from experimental rodent models to human epidemiological studies, suggests that chronic interpersonal stress may be associated with increases in systemic inflammation, which is a risk factor for early morbidity and mortality i midlife. In order to better understand these effects and potentially address them, we need to better characterize the specific social behaviors that may trigger inflammatory responses. In the rodent research, recurrent aggressive interactions with conspecifics appear to elicit systemic changes in inflammation. Similarly, laboratory evidence in humans suggests that conflictual marital interactions, especially those that are accompanied by hostile behaviors, are associated with increased concentration of circulating inflammatory markers. Little is known, however, about whether similar social behaviors may trigger inflammatory responding in the course of daily human interaction, and the extent to which these effects may account for observed associations between chronic interpersonal stress and inflammation. As part of an ongoing investigation of social relationships and health risk pathways in midlife (R01 AG041778), we are collecting observations of social interactions, mood, and inflammation, among other variables. This revision proposal adds 4 additional measures to this parent study; interview assessments of life stress; measures of glucocorticoid receptor (GCR) sensitivity; urinary catecholamines; and daily blood spot measures of interleukin-6 (IL-6), an inflammatory marker. With these additions, this study provides us with a unique opportunity to examine the social processes that may trigger inflammatory activity during everyday life, and to explore some of the mechanisms that may explain these effects. Understanding how daily social interactions may explain some of the effects of chronic interpersonal stress on health is of critical importance for developing appropriate treatment targets and methods of intervention in this area.