FASEB Summer Research Conference on Molecular Mechanisms of Immune Cell Development and Function

 描述（由申请人提供）：本申请的具体目的是为美国实验生物学学会联合会（FASEB）主办的主题为“免疫细胞发育和功能的分子机制”的夏季研究会议（SRC）获得部分支持。“这个会议，最初题为“淋巴细胞和免疫系统：分子，细胞和互动机制”，已被选定为赞助FASEB后，每隔一年的竞争性重新评估，因为它在2003年夏天成立。这次会议的特点如下。(1)会议重点关注免疫细胞发育和激活中基因调控的分子生物学，包括全基因组方法的新见解。(2)指导免疫受体基因突变的分子机制是一个重点，解释识别特异性的基础，也建立了远程基因组控制机制的先例。(3)该计划有意将对不同类别免疫细胞的研究并列，以便可以看到发育选择的机制和共享使用特定分子机制的更大模式。(4)许多演讲者明确关注基因网络和信号网络连接，而不是“一次一个基因”的研究，以提供生物调控的最全面的解释。(5)时间表将整合来自多个层次的科学家的演讲，从国际知名专家到初级博士后和研究生演讲者，在一个密集的，全全会程序。因此，年轻的受训者很容易接触到有经验的高级人物，他们可以欣赏年轻人的个人想法。(6)我们正在为2015年会议实施一种独特的财务模式，其中受邀发言者同意放弃对其参与的财务支持，以便我们能够使用我们的所有资金来支持刚刚开始建立独立职业生涯的学员和其他年轻调查员。本次会议得到了前几次会议与会者的热烈反馈，并得到了长期持续下去的有力授权。本申请中要求的资金将为2015年夏季的会议提供所需的支持，这是这一非常成功的系列会议中的第七次会议。在经费紧张的时候，许多实验室不愿意或不能派有前途的受训人员参加重要会议。同样，试图建立独立职业生涯的年轻研究人员也无法支付参加会议的费用。所要求的支持是至关重要的，使最有前途的学员和初级教师在分子免疫学公开展示他们的工作，并在一个亲密的环境中与领导人在他们的领域进行互动。

 DESCRIPTION (provided by the applicant): The specific aim of this application is to obtain partial support for a Summer Research Conference (SRC) sponsored by the Federation of American Societies for Experimental Biology (FASEB) on the subject of "Molecular Mechanisms of Immune Cell Development and Function." This conference, originally titled "Lymphocytes and the Immune System: Molecular, Cellular, and Interactive Mechanisms", has been chosen for sponsorship by FASEB after a competitive re-evaluation every other year since its inception in summer 2003. The distinctive features of this conference are the following. (1) The meeting places strong emphasis on molecular biology of gene regulation in immune cell development and activation, including new insights emerging from genome-wide approaches. (2) Molecular mechanisms guiding immune receptor gene mutagenesis are an emphasis, explaining the basis of recognition specificity and also establishing precedents for long-range genomic control mechanism. (3) The program deliberately juxtaposes research on different classes of immune cells, so that mechanisms underlying developmental choices and larger patterns of shared use of particular molecular mechanisms can both be seen. (4) Many presenters have an explicit focus on gene network and signaling network connections rather than "one gene at a time" studies, to provide the most comprehensive available explanations of biological regulation. (5) The schedule will integrate presentations from scientists at many levels, from internationally renowned experts to junior postdoctoral and graduate student speakers, in an intensive, all-plenary program. As a result, young trainees have uncommonly easy access to experienced senior figures, who can gain an appreciation for the young people's individual ideas. (6) We are implementing a unique financial model for the 2015 meeting, in which the invited speakers have agreed to forego financial support for their participation to allow us to use all of our funds to support trainees and other young investigators who are just beginning to establish their independent careers. This meeting has received enthusiastic feedback from conference attendees of the previous meetings and a strong mandate for long-term continuation. The funds requested in the present application would provide needed support for the conference in the summer of 2015, which is the 7th conference in this highly successful series. At this time when funding is tight, many laboratory are unwilling or unable to send promising trainees to important conferences. Similarly, young investigators attempting to establish their independent careers are unable to cover the costs of conference attendance. The support requested is crucial to make it possible for the most promising trainees and junior faculty in molecular immunology to publicly present their work and interact in an intimate setting with leaders in their field.