Training Program in Cardiovascular Applied Research and Entrepreneurship

描述（由申请人提供）：能够成功商业化并应用于临床环境的新心血管技术的创造依赖于一系列技能和知识，包括工程、心血管科学和企业家精神。目前的培训环境不能培养单个人的这些技能，因此，形成了高度专业化的专业人员团队。不可避免地，各个学科之间存在着沟通障碍，在从想法构思到成功商业化的漫长而艰巨的过程中，这些障碍总是造成效率低下。我们提出了一种培训转化心血管研究人员的新范式，包括在三个主要学科（工程、心血管科学和创业）中有效地获得基本技能集（或“流畅性”）。该培训项目被称为心血管应用研究与创业（CARE），所有学员将攻读生物医学工程博士学位。学员通过三个现有的途径（或“喂食计划”）进入该计划，包括医学科学家培训计划（MSTP），数学计算生物学（MCB）“门户”计划，或生物医学工程的常规博士计划。获得流畅性的机制包括传统的教学课程、获得博士学位的原创研究、培训俱乐部、指导、创建学习组合以及参加UCI的年度商业竞赛。我们还将为学员创建一个家，并利用UCI爱德华兹生命科学中心先进心血管技术的资源。该项目将培养一批新的心血管研究人员，他们可以更有效地开发可翻译的技术，并与专业企业家和临床医生进行更有效的沟通。因此，该计划将加快大学实验室基础研究成果的商业化进程。

DESCRIPTION (provided by applicant): The creation of new cardiovascular technology that can be successfully commercialized and deployed in the clinical environment relies on an array of skills and knowledge including engineering, cardiovascular science, and entrepreneurship. Current training environments are not structured to cultivate these skills in a single individual, and, as such, teams of highly specialized professionals are formed. Inevitably, barriers to communication exist between the disciplines that invariably create inefficiencies in the long and arduous process from idea conception to successful commercialization. We propose a new paradigm for training translational cardiovascular researchers that includes the efficient acquisition of a base skill set (or "fluency") in three major disciplines (engineering, cardiovascular science, and entrepreneurship). The training program is referred to as Cardiovascular Applied Research and Entrepreneurship (CARE), and all trainees will pursue the doctoral degree in biomedical engineering. Trainees enter the program through three existing pathways (or "feeder programs") that include the medical scientist training program (MSTP), a mathematical computational biology (MCB) "gateway" program, or the regular doctoral program in biomedical engineering. Mechanisms to acquire fluency range from traditional didactic courses, original research leading to the doctoral degree, training clubs, mentoring, creating a learning portfolio, and participation in UCI's annual business competition. We will also create a home for the trainees and leverage resources from The Edwards Life sciences Center for Advanced Cardiovascular Technology here at UCI. The program will create a new breed of cardiovascular researchers who can develop translatable technology more efficiently, and communicate more effectively with professional entrepreneurs and clinicians. Hence, the program will accelerate the process of commercializing basic research findings from the university lab.