International Research Collaboration on Neuroimaging Studies of Alcoholism

描述（由申请人提供）：本申请是为响应项目公告（PA）编号PAR-11-282“酒精和酒精中毒国际研究合作”而编写的U01合作协议奖励的竞争性续期申请。获得这一奖项将使我们能够继续开展国际合作项目，其中包括法国国家医学研究所/卡昂大学由Francis Eustache博士领导的知名国家资助研究小组，韩国首尔延世大学附属Severance医院由Young-Chul Jung医学博士领导的最近成立的成瘾研究项目，以及主要由NIAAA资助的长期神经成像和神经科学实验室。在美国斯坦福大学与伊迪丝·沙利文博士，首席研究员（MPI）和在SRI国际与阿道夫·普费弗鲍姆，医学博士（MPI）。这项合作的总体目标是：1)利用神经影像学、神经心理学和营养生物标志物，在有和没有KS的酗酒者和对照组中比较和对比酒精对不同国家的大脑结构和功能的影响；2)识别酒精的标志物

DESCRIPTION (provided by applicant): This application for a competing renewal of a U01 cooperative agreement award is written in response to Program Announcement (PA) number PAR-11-282, "International Research Collaboration on Alcohol and Alcoholism." Receipt of this award would enable us to continue a program of international collaborations among the well-established nationally funded research groups at INSERM/University of Caen site in France directed by Francis Eustache, Ph.D., the recently-established addictions research program at the Yonsei University affiliated Severance Hospital in Seoul, South Korea directed by Young-Chul Jung, M.D., Ph.D., and our longstanding neuroimaging and neuroscience laboratories funded principally by NIAAA, in the United States at Stanford University with Edith Sullivan, Ph.D., Principal Investigator (MPI) and at SRI International with Adolf Pfefferbaum, M.D. (MPI). The overarching aim of this collaboration is 1) to use neuroimaging, neuropsychology, and biomarkers of nutrition in alcoholics, with and without KS, and controls to compare and contrast the effects of alcohol on brain structure and function across nations and 2) to identify markers of nutritional status, genetic variants, and alcohol consumption patterns that modulate the principal dependent measures and explain heterogeneity in presentation and recovery of alcoholism. Three specific aims with testable hypotheses are proposed: 1. Prospectively screen with common diagnostic DSM-V criteria 100 alcoholics, 100 controls, and 10 KS in each country-U.S., France, and South Korea-and acquire the following data: 1a. Neuroimaging (MRI, FLAIR, DTI, and rs-fMRI) data using common protocols developed over the current funding period. 1b. Neuropsychological data using the common long and newly developed short test batteries. 1c. Blood for analysis of biomarkers of nutritional status (hemogram for red blood cell count, hematocrit, hemoglobin, mean corpuscular volume; vitamin B1 (whole blood thiamine diphosphate), folate, B12 and cerebrovascular risk factor (homocysteine). 1.d. Blood for analysis of thiamine transporter genotyping 2. Implement a secure pipeline for data reception, storage, analysis, and dissemination to and from project sites. 3. Conduct data analysis and hypothesis testing in collaboration with the project scientists (French and Korean visiting the U.S. and U.S. visiting France and Korea) and export results and analysis procedures to France and Korea.