Research Training in Infection and Immunity

描述（由申请人提供）：这是NRSA竞争更新申请的重新提交，该申请旨在培养处于传染病和免疫研究前沿的研究人员。受训人员将在博士后水平和MD和博士的混合物，每个支持2年，总要求3津贴/年。来实现这一目标。在这个时候，我们是唯一的NRSA存在于德克萨斯州医学中心，支持非艾滋病感染和全球健康的临床研究培训。一流的培训机会存在于许多领域的培训。参与计划由23位导师指导（8名医学博士，4名医学博士/博士和11名博士）具有良好的联邦资助和培训经验的记录包括：1）先天免疫的细胞和结构生物学，2）基于新药、细胞和益生菌的治疗，3）病毒和细菌性胃肠炎，4）病毒和细菌性肿瘤发生，5）疫苗开发和评估，6）病毒和细胞纳米机器的高分辨率结构，7）病原体的功能基因组学，以及8）与设备相关的感染。2014财年，参与该NRSA计划的项目的总赠款支持约为3300万美元。感染和免疫研究培训方案的结构包括受训人员可以从事的三个培训轨道：1）基于实验室的临床研究，2）临床试验和流行病学研究，3）全球卫生研究。项目总监，大卫J. Tweardy医学博士，保持该计划的最终权威和管理日常运作。他由执行委员会的另外两名成员协助，副项目主任玛丽埃斯蒂斯博士和彼得霍特兹医学博士，国家热带医学院院长。学员的选择是由选拔委员会，其中包括执行委员会和其他三个程序的教师进行。医学博士研究员的培训计划包括研究轮换，以促进导师的选择。MD和PhD学员都有单独的研究委员会，必须准备一份书面研究提案向研究委员会进行辩护，并进行年度审查，其中包括学术和职业评估。MD和PhD研究员都需要参加每月的研究进展系列研讨会，每周的期刊俱乐部和每年的科学社会。所有受训人员必须出席这些会议。成人和儿科传染病培训计划在卫生部和其他部门参与这个NRSA已经表明，他们可以吸引高素质的，培训补助金合格的博士后实习生候选人，包括近两个代表性不足的少数民族候选人每年。到目前为止，已有12名受训人员完成了该奖项支助的培训。作为一个群体，他们共发表了118篇来自博士后奖学金培训的同行评审手稿（每位毕业生9.8篇手稿; 59%由毕业生首次撰写）。此外，这些毕业生还从NIH和其他竞争来源获得了总计490万美元的外部资金。除了一名毕业生外，所有毕业生都继续从事学术或行业为基础的传染病职业。

DESCRIPTION (provided by applicant): This is the resubmission of a NRSA competing renewal application for Years 12-17 of a training program designed to produce investigators at the cutting edge of research in infectious diseases and immunity. Trainees will be at the postdoctoral level and a mixture of MDs and PhDs each supported for 2 years for a total request of 3 stipends/yr. to accomplish this goal. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center that supports clinical research training in non-AIDS infections and global health. Superb training opportunities exist at BCM in a number of areas. Participating projects directed by 23 mentors (8 MDs, 4 MD/PhDs and 11 PhDs) with strong records of federal funding and training experience include: 1) Cellular and Structural Biology of Innate Immunity, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Oncogenesis, 5) Vaccine Development and Evaluation, 6) High- resolution Structures of Viruses and Cellular Nanomachines, 7) Functional Genomics of Pathogens, and 8) Device-related Infections. Total grant support in FY2014 for the projects participating in this NRSA Program is approximately $33M. The structure of the Program for Research Training in Infections and Immunity contains three training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical trials and epidemiology research and 3) global health research. The Program Director, David J. Tweardy MD, maintains ultimate authority for the program and manages day-to-day operations. He is assisted by two other member of the Executive Committee, Associate Program Director, Mary Estes PhD, and Peter Hotez MD PhD, Dean of the National School for Tropical Medicine. Selection of trainees is performed by the Selection Committee, which includes the Executive Committee and three other program faculty. The training program for MD fellows includes research rotations to facilitate selection of a mentor. Both MD and PhD trainees have individual research committees, must prepare a written research proposal to be defended to the research committee, and have yearly reviews that include academic and career assessment. Both MD and PhD fellows are required to attend a monthly research-in-progress seminar series, a weekly journal club, and a yearly scientific social. All trainees must present at these meetings. The Adult and Pediatric Infectious Diseases Training Programs at BCM and other Departments participating in this NRSA have shown they can attract highly qualified, training- grant eligible postdoctoral trainee candidates including nearly two under-represented minority candidates per year. Twelve trainees have completed training supported by this Award, thus far. As a group, they have published a total of 118 peer-reviewed manuscripts resulting from their postdoctoral fellowship training (9.8 manuscripts per graduate; 59% first-authored by the graduate). In addition, these graduates have been awarded a total of $4.9M in external funding from the NIH and other competitive sources. All but one graduate continues to pursue an academic or industry-based infectious diseases career.