Histology

科赫研究所成员使用脊椎动物模型生物作为关键工具来研究已知或假定的 癌症基因与肿瘤的发生发展；研究肿瘤发生、发展的机制 和转移；评估间质和免疫反应在肿瘤发生中的作用；评估疗效 药物、纳米材料和设备在治疗和诊断方面的应用。因此，至关重要的是 中心成员能够正确诊断发育和肿瘤表型，评估潜在的 分子事件，并准确和定量地评估药物或疫苗投放和治疗反应。 科赫研究所组织学核心是一个共享资源，为 支持这些研究。这包括在组织切片、载玻片准备和 分析，并获得国际公认的兽医病理学家Dr。 罗德里克·布朗森用于肿瘤和发育表型的诊断。在当前时期，能力 这一核心的部分已得到扩展和加强。这包括搬进更大的、定制设计的空间 在新的科赫研究所大楼，增加了工作人员和购置了新的仪器，包括 增加了自动免疫组织化学和特殊染色功能。值得注意的是，在同一时期， 中心成员对组织学核心的使用率从53%增加到67%，其中包括来自 所有四个项目。因此，这种共享资源对于科赫研究所任务的成功至关重要。在 在接下来的一段时间里，组织学核心将继续提供广泛的最先进的组织学服务 支持中心成员的研究项目。尽管服务显著扩展，而且 因此，运行此核心的成本增加，因此请求的CCSG在44年的预算基本相同 作为第三十九年所要求和建议的预算。

Koch Institute Members use vertebrate model organisms as a key tool to study the role of known or putative cancer genes in development and tumorigenicity; investigate the mechanisms of tumor initiation, progression and metastasis; evaluate the role of stroma and immune responses in tumorigenesis; and assess the efficacy of drugs, nanomaterials and devices in therapeutic and diagnostic applications. Thus, it is essential that Center Members are able to correctly diagnose developmental and tumor phenotypes, evaluate the underlying molecular events, and accurately and quantitatively assess drug or vaccine delivery and therapeutic response. The Koch Institute Histology Core is a Shared Resource that provides state-of-the-art histological services to support these studies. This includes assistance and/or training in tissue sectioning, slide preparation and analysis, and access to the consultative services of an internationally recognized Veterinary Pathologist, Dr. Roderick Bronson for diagnosis of tumor and developmental phenotypes. In the current period, the capabilities of this Core have been expanded and enhanced. This includes moving into a larger, custom-designed space in the new Koch Institute building, an increase in the staff and the acquisition of new instrumentation including the addition of automated immunohistochemistry and special staining capabilities. Notably, in the same period, usage of the Histology Core by Center Members increased from 53% to 67%, and included investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, the Histology Core will continue to offer a wide range of state-of-the-art histological services to support the research programs of Center Members. In spite of the significant expansion of services, and the resulting increased costs of running this Core, the requested CCSG budget for Year 44 is essentially the same as the requested and recommended budget in Year 39.