Core D - Neuropathology Core

神经病理学核心项目摘要/摘要 神经病理学核心的基本哲学是这样一种信念，即诊断的有效性对于 神经退行性疾病的临床研究以及基于组织和其他生物样品的研究是一种 这是对这些疾病潜在生物过程的体外研究的重要补充。从这两根柱子 对于临床和科学界，CORE能够为减轻痛苦做出贡献 与阿尔茨海默病及相关疾病有关。因此，核心支持MADRC的总体使命 通过收集、表征、存储和分发脑组织和其他生物样品(CSF， 血浆、DNA、RNA等)来自具有良好临床特征的受试者。 来自岩心的样本在我们对生物过程的理解方面做出了重大贡献 这是早期和后期神经退行性疾病的特征。 核心将通过收集、表征和分发样本来促进对AD的研究 通过与NACC(AIMS)共享数据，提供给个人调查人员、较大的财团和合作团体 1-4)。核心的活动有创新的组成部分，专注于开发新的组织 高分辨率显微镜的处理方法，这对于了解AD的早期事件非常重要 开发新的图像共享和分析方法，并利用大型 流行病学研究，收集对照和早期受试者的样本(目标5-7)。最后，还有一个 核心的教育部分：培训神经病理学家成为诊断神经退行性疾病的专家 疾病和组织储存库的运作，以支持研究；教授其他健康知识 向专业人士宣传身体解剖和组织捐赠对研究的重要性(目标8和9)。核心是 融入所有中心活动，与行政、临床和外展中心积极互动 关于尸检许可和教育，与数据核心关于数据存储和通信 与NACC合作，与项目合作。项目2和项目3都依赖于核心的神经病理样本， 我们对大脑的常规评估包括对脑白质的关注，这是对项目1《S》的补充 连接组研究。我们还支持当地研究界和国家倡议，提出了309项请求 用于过去4年的材料(包括3600个冷冻组织样本和17,000个未染色切片)。 因此，核心活动在促进AD和其他方面的研究方面发挥着越来越大的作用 精神错乱的疾病。

NEUROPATHOLOGY CORE PROJECT SUMMARY/ABSTRACT The underlying philosophy of the Neuropathology Core is the belief that validation of diagnosis is critical to clinical research into neurodegenerative diseases and that tissue- and other biospecimen-based studies are a vital complement to in vitro studies of the biologic processes underlying these diseases. From these two pillars to the clinical and scientific community, the Core is able to make a contribution to the amelioration of suffering associated with AD and related disorders. The Core therefore supports the overall mission of the MADRC through the collection, characterization, storage and distribution of brain tissue and other biospecimens (CSF, plasma, DNA, RNA, etc) from subjects who have been well-characterized clinically. Samples from the Core have contributed to significant advances in our understanding of the biologic processes that characterize neurodegenerative diseases, both at early and later stages. The Core will serve to catalyze research into AD through collection, characterization and distribution of samples to individual investigators, larger consortia and collaborative groups and through data sharing with NACC (Aims 1-4). There are components of the Core's activities which are innovative, focused on developing novel tissue handling methods for high resolution microscopy which is important for understanding of early events in AD, on developing novel methods for imaging sharing and analysis and on harnessing opportunities provided by large epidemiologic studies to gather samples from control and early stage subjects (Aims 5-7). Finally, there is an educational component of the Core: training neuropathologists to be expert in diagnosis of neurodegenerative diseases and in the operations of tissue repositories in support of research; and teaching other health professionals about the importance of autopsy and tissue donation for research (Aims 8 & 9). The Core is integrated into all Center activities with active interactions with Administrative, Clinical and Outreach Cores regarding autopsy permission and education, with the Data Core regarding data storage and communication with NACC, and with the projects. Projects 2 and 3 both depend on neuropathological samples from the Core, and our routine evaluation of brains includes attention to the white matter, which complements Project 1's Connectome studies. We also support the local research community and national initiatives, with 309 requests for materials over the past 4 years (including >3600 frozen tissue samples and >17,000 unstained section). Thus, there is an ever-increasing role for the activities of the Core in contributing to research in AD and other dementing illnesses.