Small Animal Radiation Research Platform @ Stanford

描述（申请人提供）：斯坦福大学被公认为放射治疗发展和研究的领导者，从1955年首次使用医用直线加速器到20世纪70年代和80年代对肿瘤缺氧对治疗反应的影响的理解，到20世纪90年代调强放射治疗的发展，再到正在进行的成像技术的发展，引导放射治疗然而，斯坦福大学缺乏一个系统，提供放射治疗的小动物与适形性和图像引导常规实现在诊所。因此，我们请求资金从XStrahl购买小动物辐射研究平台（SARRP）。SARRP是一种紧凑型辐照器，采用安装在旋转框架上的225 kVp X射线束，能够从多个角度提供光束，并结合准直器来整形光束。此外，SARRP可以采集和重建锥形束X射线计算机断层扫描数据，便于使用体积成像来指导放射治疗。该系统将由跨多个部门（放射肿瘤学、放射学、儿科学、医学）和研究兴趣（肿瘤和正常组织放射生物学、干细胞和技术开发）的核心用户组成的一组内聚体使用。PI在小动物放射治疗系统的开发方面有着良好的记录，并组建了一个团队在斯坦福大学的研究环境中部署和管理该设备。有了这项新技术，我们将大大提高NIH资助研究的转化潜力，并将开发新的科学和技术。

DESCRIPTION (provided by applicant): Stanford University is recognized as a leader in the development and study of radiation therapy, from the first use of the medical linear accelerator in 1955 to the understanding of the influence of tumor hypoxia on therapeutic response in the 1970's and 1980's to the development of intensity-modulated radiation therapy in the 1990's to the ongoing development of image-guided radiation therapy. However, Stanford lacks a system for delivering radiotherapy to small animals with the conformality and image guidance routinely achieved in the clinic. We therefore request funds to purchase a Small Animal Radiation Research Platform (SARRP) from XStrahl. The SARRP is a compact irradiator employing a 225 kVp x-ray beam mounted on a rotating frame, capable of delivering beams from multiple angles and incorporating collimators to shape the beam. In addition, the SARRP can acquire and reconstruct cone beam x-ray computed tomography data, facilitating the use of volumetric imaging to guide radiation therapy. This system will be employed by a cohesive set of core users spanning multiple departments (Radiation Oncology, Radiology, Pediatrics, Medicine) and research interests (tumor and normal tissue radiobiology, stem cells, and technology development). The PI has a track record in the development of small animal radiotherapy systems and has assembled a team to deploy and manage this device within the Stanford research environment. With this new technology we will significantly enhance the translational potential of NIH funded research and will develop new science and technology.