Neuroscience Advanced Predoctoral institutional Training Grant

描述(由申请人提供)：神经科学高级博士前培训计划的中心目标是培养对神经动力学的理论、实践和临床重要性有高度理解的研究生。具有适当背景课程和研究兴趣的学生将被录取参加这项高级培训计划，4名学生将从该培训补助金中获得直接资助。深入了解神经动力学背后的基本机制，对于理解健康的行为和在神经疾病中观察到的许多严重缺陷至关重要。这一主题跨越了神经科学研究的几乎所有层面：生物物理学决定了动作电位的激发模式，进而决定了神经元之间传递的概率，并最终 神经电路或分布式表示可以携带的信息。布朗大学有 在所有这些层面上都有很强的专业知识，从潜在行为的神经动力学的遗传基础到基于高级目标的信息处理动态控制的认知神经科学研究。神经动力学方面的缺陷被广泛认为是癫痫和帕金森氏症等疾病的病理生理学基础。董事黛安·利普斯康姆和克里斯·摩尔拥有互补的专业知识，是神经动力学高级培训计划的理想选择。他们将从外部和内部咨询小组以及学生那里获得建议，以继续调整和改进培训计划。神经动力学培训计划将在布朗的神经科学研究生计划中进行管理和执行。布朗大学的神经科学研究生项目提供以学生为中心的高质量培训，我们的大多数毕业生都追求神经科学的职业生涯。学生还将接触到计算、翻译和临床方法。早期的多学科训练与神经动力学的这种专门的高级训练很好地吻合。该培训计划将提供三个基本要求，以培养具有强大神经动力学培训的学生：首先，需要详细了解神经动力学研究中的知识状况和定义辩论，并将在讲座和研讨会课程中向学生传授。基础知识的培训将与实验实践的强化培训相结合，向学生传授动力学研究的科学设计的基本原则，以及用于解决神经动力学研究中的争论和检验假设的前沿方法。学生们还将设计自己的神经动力学实验(S)，然后在海洋生物实验室进行为期9天的强化实践。其次，在布朗大学有29个实验室研究这一课题的世界级环境，对于促进在这一课题上的长期、深入的博士前研究至关重要。第三，接触国内机构以外的观点，最重要的是超越古典学术界本身，将扩大学生对这一重要主题的理解和视角。

DESCRIPTION (provided by applicant): The central objective of this advanced predoctoral training program in Neuroscience is to produce graduate students with a high level understanding of the theory, practice, and clinical importance of neural dynamics. Students with appropriate background coursework and research interests will be enrolled in this advanced training plan, a subset of 4 students will receive direct funding from this training grant. Deep knowledge of the basic mechanisms underlying neural dynamics is crucial to understand healthy behavior and many of the profound deficits observed in neurological disease. This topic spans almost all levels of neuroscience inquiry: Biophysics determines patterns of action potential firing, which in turn determines the probability of relay between neurons, and ultimately the information that a neural circuit or distributed representation can carry. Brown University has strong expertise across all these levels, ranging from the genetic bases of neural dynamics underlying behavior through the cognitive neuroscientific study of dynamic control of information processing based on high-level goals. Failures in neural dynamics are widely hypothesized to underlie the pathophysiology of maladies such as epilepsy and Parkinson's disease. The directors, Diane Lipscombe and Chris Moore, have complementary expertise ideal for an Advanced Training Plan in neural dynamics. They will receive advice from external and internal advisory groups and from students, to continue to adapt and improve the training plan. The Neural Dynamics training program will be managed and administered within Brown's Graduate Program in Neuroscience. The Neuroscience Graduate program at Brown offers student-centered, high-quality training and the majority of our graduates pursue careers in neuroscience. Students are also exposed to computational, translational, and clinical approaches. Early multi-disciplinary training dovetails well with this specialized advanced training in Neural Dynamics. This Training Program will provide three basic requirements to produce students with strong training in Neural Dynamics: First, a detailed understanding of the state of knowledge and the defining debates in the study of neural dynamics is required, and will be imparted to students in lectures and seminar courses. This training in basic knowledge will be paired with intensive training in experimental practice to teach students basic principles of scientific design of dynamics studies, and in the cutting edge methods used to resolve debates and test hypotheses in the study of neural dynamics. Students will also design their own experiment(s) on a topic in neural dynamics, and then execute these studies in an intensive 9-day practicum at the Marine Biological Laboratory (MBL). Second, a world-class environment of 29 laboratories investigating this topic at Brown is crucial to foster long-term, in-depth predoctoral research on this topic. Third, access to perspectives beyond those of the home institution, and most importantly beyond classical academia itself, will expand students' understanding and perspective on this important topic.