CLINICAL AND IMAGING CORE SUPPORT OF ACUTE STROKE RESEARCH

急性卒中转化研究计划的基础是急性卒中临床服务，它将确保最大限度地转介患者，并允许及时识别、筛选和招募潜在研究对象，以研究脑缺血的早期事件并将患者纳入急性卒中研究方案。由于缺乏急诊科，以及筛选和招募急性中风患者作为研究对象的时间限制，NIH临床中心无法成为我们研究项目的主要地点。因此，我们已经在当地医院、马里兰州贝塞斯达的郊区医院(SH)和华盛顿特区的MedStar华盛顿医院中心(MWHC)建立并维护了支持此类计划所需的临床、成像和研究基础设施。这些地点也是我们ACGME认证的血管神经学奖学金培训计划的主要培训地点。这一基础设施的主要组成部分包括NIH卒中服务，这是NIH和合同工临床医生卒中神经学家、护士、临床研究员、现场研究/护士协调员和核磁共振技术专家的组合。美国国立卫生研究院的计算机网络已经扩展到每个地点。此外，NIH还在MWHC放置了一台3T磁共振扫描仪，并在上海共享了一台3T磁共振扫描仪。我们为MWHC和SH MRI扫描仪上获得的图像维护自己的PAC，并开发和维护临床和研究患者数据的注册表。在过去的一年里，我们筛选了大约1125名患者，并将大约105名患者纳入了我们的一项临床研究方案。

The foundation of an acute stroke translational research program is an acute stroke clinical service that will assure maximum patient referral and allow rapid identification, screening and recruitment of potential research subjects in the timely fashion needed to study the early events in cerebral ischemia and enroll patients in acute stroke research protocols. Absence of an emergency department and the time constraints on screening and recruitment of acute stroke patients as research subjects has precluded the NIH Clinical Center as the main site of our research projects. Thus, we have established and maintained the clinical, imaging and research infrastructure required to support such a program at local hospitals, Suburban Hospital (SH) in Bethesda, Maryland, and MedStar Washington Hospital Center (MWHC) in DC. These sites also serve as the key training locations for our ACGME accredited vascular neurology fellowship training program. The major elements of this infrastructure include the NIH Stroke Service, a combination of NIH and contractor clinicians stroke neurologists, nurses, clinical fellows, on-site research/nurse coordinators and MRI technologists. The NIH computer network has been extended to each site. In addition NIH has placed a 3T MRI scanner at MWHC and shares a 3T MRI scanner at SH. We maintain our own PACS for images obtained on the MWHC and SH MRI scanners, and developed and maintain a registry for clinical and research patient data. In the past year we screened approximately 1125 patients and enrolled approximately 105 patients into one of our clinical research protocols.