Experimental Pathology of Cardiovascular Disease

 描述（由申请人提供）：我们申请在华盛顿大学医学院继续支持36至40年的心血管疾病实验病理学培训计划（CVP）。CVP是一个机构性的国家研究服务奖（NRSA），自1978年以来一直由NHLBI资助。我们的建议建立在培养独立的科学家在前和博士后水平的强大传统。自20世纪70年代早期血管生物学作为细胞生物学领域开始以来，CVP在该领域发挥了重要作用。我们的重点仍然是使用创新工具研究心脏和血管。我们今天的重点是干细胞生物学，膜生物学，遗传学和基因组学。CVP继续通过培训新的独立调查人员来专注于创新，他们从我们教师广泛的跨学科研究所产生的协同效应中受益。这项合作是将研究转化为临床疾病应用的重要桥梁，包括动脉粥样硬化，高血压和心力衰竭。治疗的机会将增长出我们的主要关注点在干细胞生物学，再生医学和遗传学。该项目是华盛顿大学和太平洋西北地区心血管生物学和干细胞生物学基础科学培训的主要支持来源。

 DESCRIPTION (provided by applicant): We are applying to sustain support for years 36 to 40 of The Experimental Pathology of Cardiovascular Disease Training Program (CVP) at the University of Washington's School of Medicine. CVP is an institutional National Research Service Award (NRSA) that has been continuously funded by the NHLBI since 1978. Our proposal builds upon a strong tradition of training independent scientists at both the pre- and postdoctoral levels. Since vascular biology began as a field of cell biology in the early 1970's, CVP has played a major role in this field. Our focus continues to be on the study of heart and blood vessels using innovative tools. Our emphasis today is on stem cell biology, membrane biology, genetics and genomics. CVP continues to focus on innovation by training new independent investigators who benefit from the synergies produced by the extensive interdisciplinary research of our faculty. This collaboration is an important bridge to translate research into applications important to clinical diseases including atherosclerosis, hypertension, and heart failure. Therapeutic opportunities will grow out of our major foci of interest in stem cel biology, regenerative medicine and genetics. This program is the major source of support for basic sciences training in cardiovascular biology and in stem cell biology at the University of Washington and in the Pacific Northwest.