Pediatric Neurology Physician Scientist Program.

描述(申请人提供)：发育神经科学、成像、遗传学和分子治疗学的快速发展将儿童神经学推到了生物医学的聚光灯下。作为一名儿童神经学住院医生项目主任，我对每一波新的住院医生申请者越来越引人注目的资质感到惊讶，他们被我们专业面临的根本问题所吸引。在马萨诸塞州总医院，我们拥有一批对研究感兴趣的有才华的住院医生，大量的基础科学进展等待转化为医学现实，极其丰富的研究环境，以及PI、指导委员会和一群精心挑选的导师，他们将共同指导这些受训人员发展成为成功的内科科学家。我们召集了一群由美国国立卫生研究院资助的有成就的导师，他们的专业知识集中在儿童的大脑发育和神经疾病上。这些都是经验丰富的调查人员，在培训内科科学家方面有着良好的记录。K12学员不仅可以完全访问他们导师的实验室，还可以通过旨在加速麻省总医院、哈佛医学院、哈佛公共卫生学院和麻省理工学院神经科学研究的合作项目获得许多可用的资源。精心设计的课程包括课程作业、书面评估以及与PI和儿童神经学共同导师的会议，以确保所有学者参与者都能顺利获得独立研究资金。

DESCRIPTION (provided by applicant): Rapid advances in developmental neuroscience, imaging, genetics, and molecular therapeutics have thrust Child Neurology into the biomedical limelight. As a child neurology residency program director I am amazed at the increasingly spectacular qualifications of each new wave of resident applicants who are drawn to the fundamental problems facing our specialty. At Massachusetts General Hospital we are poised with a talented pool of residents interested in research, an abundance of basic science advances waiting to be translated to medical realities, an exceptionally rich research environment, and a PI, steering committee, and group of carefully selected mentors who together will guide the development of these trainees into successful physician scientists. We have assembled a group of accomplished NIH-funded mentors whose expertise is focused on brain development and neurological diseases of childhood. These are experienced investigators with a strong track record of training physician scientists. The K12 participants will have full access not only to their mentor's lab but also the many resources available through collaborative programs designed to accelerate neuroscience research at Massachusetts General Hospital, Harvard Medical School, Harvard School of Public Health, and the Massachusetts Institute of Technology. A carefully structured curriculum of coursework, written evaluations, and meetings with the PI and child neurology co-mentors has been carefully designed to ascertain that all scholar participants advance smoothly to independent research funding.