CSHL Eukaryotic DNA Replication & Genome Maintenance Conference

 简介(申请人提供)：2015 CSHL真核DNA复制与基因组维护学术会议。遗传物质(DNA)的复制是所有单细胞和多细胞生物体的核心过程。在高等动植物中，遗传物质与特殊蛋白质一起包装在称为染色体的结构中，而染色体本身就包装在细胞核内。这些染色体是如何复制的，它们包含的DNA是如何复制的，以便一代又一代地复制出忠实的副本，这是生物学中的一个中心问题。有机体的全部DNA(其“基因组”)必须在每次细胞分裂时以最小的错误进行复制，这涉及到在分子水平上运行的多个“校对”和“纠错”机制，以确保出色的复制保真度。当细胞在癌症发展过程中开始无法控制地分裂时，错误可能会累积，这可能本身就有助于疾病的进展。这一过程的中心性和重要性，特别是与癌症发展的相关性，使一大批但不同的科学家开始研究在许多系统中的DNA复制。真核生物DNA复制和基因组维护会议的目的是提供一个论坛，将在该领域不同领域工作的不同科学家群体聚集在一起。这次会议将是一次公开的国际会议，专门讨论在快速发展的真核DNA复制和维持基因组完整性领域的最新进展。口头报告将包括特邀报告和从提交的摘要中挑选出来的报告。这确保了外地初级和高级领导人的参与，并介绍了会议期间出现的最令人振奋的成果。除了口头陈述外，还将在三个海报会议上进行海报展示，也是从提交的摘要中挑选。

 DESCRIPTION (provided by applicant): 2015 CSHL CONFERENCE IN EUKARYOTIC DNA REPLICATION & GENOME MAINTENANCE. The duplication of the genetic material (DNA) is a process central to all unicellular and multicellular organisms. In higher plants and animals, the genetic material is packaged together with specialized proteins in structures called chromosomes that are themselves packed within the cell nucleus. How these chromosomes are duplicated, and how the DNA they contain is replicated, to allow faithful copies to be made from generation to generation, is a central question in biology. The entirety of the DNA of an organism (its "genome") has to be copied with minimal errors every time the cell divides, which involves multiple "proof-reading" and error- correction" mechanisms that operate at the molecular level to ensure excellent copying fidelity. When cells begin to divide uncontrollably during the development of cancer, errors may accumulate which may themselves contribute to how the disease progresses. The centrality and importance of this process, and its relevance to the development of cancer in particular, has led a large but diverse group of scientists towards the study of DNA replication in numerous systems. The aim of the conference on Eukaryotic DNA Replication & Genome Maintenance is to provide a forum to bring together the diverse group of scientists working in different areas of this field. The conference will be an open international meeting devoted to the most recent advances in the rapidly evolving field of eukaryotic DNA replication and the maintenance of genome integrity. Oral presentations will consist of a combination of invited presentations and selected presentations from submitted abstracts. This ensures the participation of junior and senior leaders in the field and the presentation of the most exciting results emerging at the time of the meeting. The oral presentations will be complemented by poster presentations in three poster sessions, also selected from submitted abstracts.