Glucose Metabolism in Adults Prenatally Exposed to Diabetogenic Pollutants

 描述(由申请人提供)：父母建议的总体目标是评估发育中(产前或出生后)暴露于环境化学物质是否与糖代谢改变、胰岛素敏感性降低、代谢不灵活以及代谢综合征早期临床症状的发展有关。 年龄在27-28岁之间的法罗人出生队列。目前的修订：分析表明，可能导致环境相关的2型糖尿病的基因-环境相互作用。这种有针对性的方法符合法罗群岛的立法，并允许重点放在可能的基因-环境相互作用的相关基因和环境化学品的精心策划的清单上。利用HSPH的遗传实验室设施，并依赖于正在进行的父母研究，其中知情同意包括遗传研究，这一修订将解决以下问题：候选基因的异质性是否会改变葡萄糖代谢表型，因为接触非生物成因有机卤化物可能会影响这一表型。研究结果还将有助于评估遗传因素对个人易感性的影响，以及在风险评估中使用违约不确定性因素。

 DESCRIPTION (provided by applicant): The overall goal of the parent proposal is to assess whether developmental (prenatal or early postnatal) exposure to environmental chemicals may be associated with the development of altered glucose metabolism, decreased insulin sensitivity, metabolic inflexibility, and early clinical signs of metabolic syndrome development in a Faroese birth cohort by age 27-28 years. The present - Revision: analyses suggest may cause gene-environment interactions in regard to environmentally associated type 2 diabetes. The targeted approach is in accordance with Faroese legislation and allows a focus on a curated list of linked genes and environmental chemicals for possible gene- environment interaction. Using genetic laboratory facilities at HSPH and relying on the ongoing parent study, where informed consent includes genetic studies, this Revision will address the question whether heterogeneities of candidate genes may modify the glucose metabolism phenotype as potentially affected by exposures to diabetogenic organohalogen compounds. The results will also contribute to the assessment of genetic impact on individual susceptibility and the use of default uncertainty factors in risk assessment.