Crump Preclinical Imaging Core

共享资源核 克伦普临床前影像技术中心 摘要： 克伦普临床前成像技术中心将为活体成像提供全面支持 在NSBCC项目中开展的研究。在核心总监迈克尔·菲尔普斯博士的指导下， 影像中心由另外两名教员阿里恩·哈吉奥安努博士和杰森·李博士以及一名全职教师组成 工作人员。所有教职员工在临床前分子成像方面都有丰富的经验和认知。 成像中心将提供所有放射性标记的探针，执行所有的microPET和CT研究，以及数据 分析。此外，他们将向调查人员提供支持和培训，包括动物准备和 监控、质量控制和最严格的安全措施。共享资源核心的目标是 提供先进的分子成像支持，以评估肿瘤代谢动力学和治疗 对治疗干预的反应结果。这些实验将由高度受控的、连续的- 后天的正电子发射计算机断层扫描和CT扫描分别用于功能和解剖评估。因为PET无线电- 使用的标记探针也广泛应用于临床，将临床前采集的影像数据共享 RESOURCE CORE可翻译为评估患者治疗反应的生物标志物。

SHARED RESOURCE CORE CRUMP PRECLINICAL IMAGING TECHNOLOGY CENTER ABSTRACT: The Crump Preclinical Imaging Technology Center will provide comprehensive support for the in vivo imaging studies carried out in the NSBCC projects. Under the direction of Core Director Dr. Michael Phelps, the Imaging Center is comprised of two other faculty, Dr. Arion Hadjioannou and Dr. Jason Lee, and one full-time staff member. All faculty members have extensive experience and recognition in preclinical molecular imaging. The Imaging Center will provide all radio-labeled probes, perform all microPET and CT studies, and data analysis. In addition, they will provide support and training to investigators, including animal preparation and monitoring, quality control and the strictest safety measures. The goal of the Shared Resource Core is to provide advanced molecular imaging support to assess the kinetics of tumor metabolism and therapeutic outcome in response to therapeutic intervention. These experiments will consist of highly-controlled, serially- acquired PET and CT scans for both functional and anatomical assessment, respectively. Since the PET radio- labeled probe used is also widely available in the clinic, the preclinical imaging data acquired by the Shared Resource Core can be translated as biomarkers for evaluation of treatment response in patients.