Neuroimaging and Risk Factor Correlates in Aging and MCI

描述(由申请人提供)：本提案要求NIA继续为马克·W·邦迪博士颁发的以患者为中心的研究(K24)职业中期研究员奖提供资金。在K24奖项提供的头5年支持期间，Bondi博士通过使用动脉自旋标记(ASL)和扩散张量成像(DTI)MRI技术完成了重点培训，并与学员一起在他的研究实验室实施了这些技术，从而提升了自己作为研究导师的技能。在此期间，他获得了四项面向患者的研究资助(来自NIA的R01、R43和R44资助，以及来自阿尔茨海默氏症协会的研究人员发起的研究资助)。他还曾担任12名正在培训的临床医生-科学家的主要导师或共同导师。这些受训人员中有8人继续接受了来自NIH(4个NRSA；1个SC3)、退伍军人事务部(4个退伍军人职业发展奖)、国防部(2个调查员发起的补助金)和私人基金会(3个来自阿尔茨海默氏症协会的新研究员研究补助金；1个来自远方的新研究员补助金)的指导或独立研究支持，或两者兼而有之。此外，所有的受训者都发表了一篇或多篇首次发表的同行评议研究论文，报告了他们的工作(自2007年以来，发表了40篇独特的受训者论文)，他实验室的8名受训者目前在全职学术、以病人为导向的教员或研究岗位上工作。对新生的以病人为导向的研究人员的培训和支持的需求既迫切又深刻。加州大学圣迭戈分校和VASDHS幸运地拥有几个正式的培训计划(包括部门T32培训补助金和退伍军人事务部博士后奖学金计划)，以支持临床医生-科学家的结构化教学培训。 这些项目中的每一个都需要有经验丰富的导师。K24奖允许邦迪博士投入大量时间指导新的面向患者的研究人员。邦迪博士是一位久负盛名的多产临床科学家，他在神经心理学和神经成像方面的综合工作帮助我们形成了对阿尔茨海默病(AD)前驱期的理解。这也为他提供了时间来提高自己的研究技能，以便指导新的临床研究人员，并进行有价值的以患者为导向的研究。这一提议的5年持续支持的一次性机会将侧重于促进他的研究小组在神经心理学和神经成像研究方面的专业知识与他们日益增长的技能和对利用生物标记物支持表征痴呆症前驱期的兴趣的融合。在几位公认的高级神经成像和脑脊液生物标记物技术的“资源”专家的帮助下，邦迪博士建议丰富和深化他在这些领域的研究专业知识，其双重目标是(1)保持他的团队在早期检测研究方面的领先地位，(2)同时将这些技能传递给他指导的临床科学家，努力在痴呆症的早期检测、诊断和临床结果方面以患者为导向的研究中推进自己的职业生涯。

DESCRIPTION (provided by applicant): This proposal requests continued NIA funding for the Midcareer Investigator Award in Patient-Oriented Research (K24) to Mark W. Bondi, PhD. During the first 5 years of support provided by the K24 award, Dr. Bondi has upgraded his own skill set as a research mentor by completing focused training with arterial spin labeling (ASL) and diffusion tensor imaging (DTI) MRI techniques and implementing them in his research lab with his trainees. During this period, he has obtained four patient-oriented research grants (R01, R43, and R44 grants from the NIA and an Investigator-Initiated Research Grant from the Alzheimer's Association). He has also served as primary mentor or co-mentor to 12 clinician-scientists in training. Eight of these trainees have gone on to receive either mentored or independent research support, or both, from NIH (4 NRSA; 1 SC3), the Dept of Veterans Affairs (4 VA Career Development Awards), the Dept of Defense (2 Investigator-Initiated Grants), and private foundations (3 New Investigator Research Grants from the Alzheimer's Association; 1 New Investigator Grant from AFAR). Furthermore, all of the mentees have published one or more first- authored peer-reviewed research papers reporting their work (40 unique mentee publications since 2007), and eight trainees from his lab now work in full-time academic patient-oriented faculty or research positions. The need for training and support of nascent patient-oriented researchers is both acute and profound. UCSD and the VASDHS are fortunate to have several formal training programs (including departmental T32 training grants and VA post-doctoral fellowship programs) to support the structured didactic training of clinician- scientists. Each of these programs requires the availability of skilled mentors. The K24 award permits Dr. Bondi, an established and productive clinician scientist whose integrative work in neuropsychology and neuroimaging has helped to shape our understanding of the prodromal period of Alzheimer's disease (AD), to devote substantial time to mentoring new patient-oriented researchers. It also provides him with time to enhance his own research skills in order to mentor new clinical investigators and to conduct meritorious patient-oriented research. This proposed one-time opportunity for 5 years of continued support will focus on facilitating the convergence of his research group's expertise in neuropsychology and neuroimaging studies with their growing skill and interest in the utilization of biomarkers in support of characterizing the prodromal period of dementia. With the help of several identified 'resource' experts in advanced neuroimaging and CSF biomarker techniques, Dr. Bondi proposes to enrich and deepen his research expertise in these areas with the dual aims of (1) maintaining his group's efforts at the vanguard of early detection research, and (2) simultaneously transmitting these skills to the clinician scientists he mentors in an effort to advance their own careers in patient-oriented research in early detection, diagnosis and clinical outcomes in dementia.