Centralized Research Instrumentation Core (CRI)

项目摘要 PR-INBRE中央研究仪器(CRI)核心的总体目标是 整合并增强学院调查人员、学生和博士后的能力，主要是 本科生机构(PUI)和外展机构，通过提供指导和 科学支撑。PR-INBRE CRI将纳入PR-INBRE和 由美国国立卫生研究院(NIH)基础设施支持的其他协作设施 国家少数民族健康和健康差距研究所(NIMHD)资助的项目 波多黎各大学医学院校园(UPR-MSC)RCMI方案，并与UPR 机构基金。其中几个核心设施已经运行了14年或更长时间， 硕士和博士级别的经验丰富的技术人员和敬业的科学人员。以下是 设施将在下一个周期参与拟议的CRI：RCMI/PR-INBRE Human UPR-MSC遗传学和基因组学核心实验室；UPR-INBRE代谢组学核心 里约热内卢皮德拉斯的PR-INBRE测序和基因组学设施；PR-INBRE Ana G.Mendez Cupey大学校区的ChemTox生物测试核心和PR- UPR-综合癌症中心的INBRE/RCMI翻译蛋白质组学核心。他们的 努力支持地方、国家和国际合作。为实现这一总体目标， 核心提出了以下具体目标：1)继续提供获取最先进技术的途径 核心研究工具，用于培育新的研究项目和扩大已建立的 来自波多黎各的CRI调查人员、学生和博士后之间的研究合作 和其他想法状态。2)确保有效传播CRI提供的技术 通过理论和实践研讨会，指导研究人员进行实验设计， 使用研究与创新中心现有资源的数据分析和最佳做法。3) 与其他INBRE和Cobre核心实验室合作，扩大PR-INBRE的访问范围 调查人员对其他IDEA核心可用的创新技术进行调查并提供机会 为技术和科学工作人员的专业发展提供支持 诸如生物医学研究设施协会(ABRF)和 其他培训机会。协助发展跨学科的研究工作 在PR-INBRE网络机构，CRI将提供以下专门服务： 遗传学和生物医学领域的实验设计、数据生成和分析的技术咨询 人类和小动物模型系统中的基因组学、蛋白质组学、代谢组学和生物学 细菌和组织培养细胞中实验化合物的测试。

Project Summary The overall goal of the PR-INBRE Centralized Research Instrumentation (CRI) Cores is to integrate and empower Faculty investigators, students and postdocs from the Lead, Primarily Undergraduate Institutions (PUIs), and Outreach Institutions by providing mentorship and scientific support. The PR-INBRE CRI will incorporate core facilities supported by PR-INBRE and other collaborating facilities supported by National Institutes of Health (NIH) infrastructure programs such as the National Institute on Minority Health and Health Disparities (NIMHD)-funded University of Puerto Rico Medical Sciences Campus (UPR-MSC) RCMI program, and with UPR institutional funds. Several of these core facilities have been operating for 14 or more years with M.S. and Ph.D.-level experienced technicians and committed scientific staff. The following facilities will participate in the proposed CRI in the next cycle: the RCMI/PR-INBRE Human Genetics and Genomics Core Lab at UPR-MSC; the PR-INBRE Metabolomics Core at UPR- MSC; the PR-INBRE Sequencing and Genomics Facility at UPR-Rio Piedras; the PR-INBRE ChEMTox Biotesting Core at Universidad Ana G. Mendez Cupey Campus and the PR- INBRE/RCMI Translational Proteomics Core at the UPR-Comprehensive Cancer Center. Their efforts support local, national and international collaborations. To fulfill the overall goal of this Core the following specific aims are proposed: 1) Continue to provide access to state-of-the-art core research instrumentation for nurturing new research projects and expanding established research collaborations between the CRI investigators, students, and postdocs from Puerto Rico and other IDeA states. 2) Ensure the effective dissemination of technologies offered by the CRI Cores via theoretical and practical workshops, mentoring researchers in experimental design, data analysis and best practices in the use of the resources available at the CRI Cores. 3) Collaborate with other INBRE and COBRE Core labs to expand access for PR-INBRE investigators to innovative technologies available at other IDeA cores and provide opportunities for professional development of technical and scientific staff by supporting attendance to professional meetings such as the Association of Biomedical Research Facilities (ABRF) and other training opportunities. To assist in the development of an interdisciplinary research effort at the PR-INBRE network institutions, the CRI will provide specialized services such as: direct technical consultation on experimental design, data generation, and analysis in genetics and genomics in human and small animal model systems, proteomics, metabolomics, and biological testing of experimental compounds in bacteria and tissue culture cells.