Strategic and Plasticity Interventions for Late Life Depression in Community Settings

描述（由申请人提供）：这是一个中期职业导师奖的竞争性更新，最初的标题是“用CIND/aMCI治疗低收入老年人的抑郁症”，现在的标题是“社区环境中晚年抑郁症的战略和可塑性干预”。头衔的改变反映了我希望在未来五年的职业生涯中接受更多的培训。在最初的奖项中，我研究了与轻度认知障碍相关的神经心理学和行为神经学。这一经历使我能够开发出干预措施，解决心理治疗结果的认知调节因素，并指导下一代心理治疗研究人员，他们也对认知障碍和晚年情绪障碍治疗的交叉感兴趣。该奖项导致了20篇论文和5项资助申请（其中4项随后获得资助），为我所在部门的初级教师制定了一个指导计划，并为加州大学旧金山分校的9名初级教师、3名加州大学系统外的教师和7名博士后提供了个人指导。在这个提案中，我希望研究晚期生活抑郁症（LLD）的认知神经科学，并了解更多关于可塑性干预及其在LLD治疗中的潜在作用。我的目的不是改变我作为一名研究人员的身份，而是对这两个广阔的领域有足够的了解，以便我能够(1)将我从生物学理论中学到的知识与我已经掌握的关于LLD的心理学和社会学解释的知识相结合，(2)与认知神经科学家和可塑性干预学家合作，为LLD制定有针对性的行为干预措施。(3)将我在便携式和老年人友好型行为干预开发方面的专业知识加入到可塑性干预研究领域。我相信这次培训将使心理治疗和认知神经科学领域之间更好的相互交流，从而有助于改善心理健康的研究方向。因为在我们的领域很少有科学家尝试从事这种类型的交叉受精，我计划还为博士后开发一个培训课程，专注于行为干预研究和认知神经科学的交叉，培养一代心理治疗研究人员，他们可以与生物学方向的研究人员合作，治疗晚年情绪障碍。

DESCRIPTION (provided by applicant): This is a competing renewal of a mid-career mentor award that was originally titled "Treating Depression in Low-Income Elderly with CIND/aMCI" and is now titled Strategic and Plasticity Interventions for Late Life Depression in Community Settings. The title change reflects the additional training I wish to pursue in the next five years of my career. In the original award, I studied neuropsychology and behavioral neurology associated with mild cognitive impairment. This experience allowed me to develop interventions that would address cognitive moderators of psychotherapy outcomes, and to mentor the next generation of psychotherapy researchers who are also interested in the intersection of cognitive impairments and the treatment of mood disorders in late life. That award resulted in 20 papers and 5 grant applications (4 were subsequently funded), the development of a mentoring program for junior faculty in my home department and personal mentorship of 9 junior faculty at UCSF, 3 faculty outside the UC system and 7 post doctoral fellows. In this proposal, I wish to study cognitive neuroscience of late life depression (LLD) and to learn more about plasticity interventions and their potential role in the treatment of LLD. My intent is not to change who I am as a researcher, but learn enough about these two vast fields so that I can (1) integrate what I learn from biological theory with the knowledge I already possess about psychological and sociological explanations of LLD, (2) work collaboratively with cognitive neuroscientists and plasticity interventionists to develop targeted behavioral interventions for LLD, and (3) add my expertise in the development of portable and geriatric friendly behavioral interventions to the field of plasticity intervention research. I believe this training will allow for better and mutual cross fertilization between the fields of psychotherapy and cognitive neuroscience, which will serve to improve mental health research directions. Because few scientists in our field have attempted to engage in this type of cross fertilization, I plan to also develop a training curriculum for post-doctoral fellows focused on the intersection of behavioral interventions research and cognitive neuroscience, to develop a generation of psychotherapy researchers who can work collaboratively with biologically oriented researchers in the treatment of late life mood disorders.