Strategic and Plasticity Interventions for Late Life Depression in Community Settings

社区环境中晚年抑郁症的战略和可塑性干预措施

• 批准号: 8996065
• 负责人: Patricia A. Arean
• 金额: $ 17.33万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8996065
• 关键词: Address; Affect; Anterior; Antidepressive Agents; Applications Grants; Award; Behavior; Behavior Therapy; Behavioral; Biological; Brain; Brain region; Clinical; Clinical Trials; Cognitive; Color; Complex; Conflict (Psychology); Depressed mood; Development; Disease; Dorsal; Educational Curriculum; Elderly; Faculty; Fertilization; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Home environment; Impaired cognition; Intervention; Intervention Studies; Knowledge; Learning; Low income; Measures; Mental Depression; Mental Health; Mentors; Mentorship; Methods; Mood Disorders; Moods; National Institute of Mental Health; Nature; Neurobiology; Neuropsychology; Observational Study; Outcome; Paper; Participant; Patients; Pattern; Performance; Persons; Postdoctoral Fellow; Prefrontal Cortex; Process; Psychotherapy; Recommendation; Recruitment Activity; Research; Research Personnel; Role; Sampling; Scanning; Science; Scientist; System; Thinking; Time; Training; Visit; Work; World Health Organization Disability Assessment Schedule; base; behavioral neurology; career; cingulate cortex; cognitive neuroscience; community setting; disability; environmental change; ethnic diversity; executive function; experience; geriatric depression; improved; interest; mild cognitive impairment; next generation; novel strategies; problem solving therapy; programs; psychologic; response; skills; theories; treatment response

DESCRIPTION (provided by applicant): This is a competing renewal of a mid-career mentor award that was originally titled "Treating Depression in Low-Income Elderly with CIND/aMCI" and is now titled Strategic and Plasticity Interventions for Late Life Depression in Community Settings. The title change reflects the additional training I wish to pursue in the next five years of my career. In the original award, I studied neuropsychology and behavioral neurology associated with mild cognitive impairment. This experience allowed me to develop interventions that would address cognitive moderators of psychotherapy outcomes, and to mentor the next generation of psychotherapy researchers who are also interested in the intersection of cognitive impairments and the treatment of mood disorders in late life. That award resulted in 20 papers and 5 grant applications (4 were subsequently funded), the development of a mentoring program for junior faculty in my home department and personal mentorship of 9 junior faculty at UCSF, 3 faculty outside the UC system and 7 post doctoral fellows. In this proposal, I wish to study cognitive neuroscience of late life depression (LLD) and to learn more about plasticity interventions and their potential role in the treatment of LLD. My intent is not to change who I am as a researcher, but learn enough about these two vast fields so that I can (1) integrate what I learn from biological theory with the knowledge I already possess about psychological and sociological explanations of LLD, (2) work collaboratively with cognitive neuroscientists and plasticity interventionists to develop targeted behavioral interventions for LLD, and (3) add my expertise in the development of portable and geriatric friendly behavioral interventions to the field of plasticity intervention research. I believe this training will allow for better and mutual cross fertilization between the fields of psychotherapy and cognitive neuroscience, which will serve to improve mental health research directions. Because few scientists in our field have attempted to engage in this type of cross fertilization, I plan to also develop a training curriculum for post-doctoral fellows focused on the intersection of behavioral interventions research and cognitive neuroscience, to develop a generation of psychotherapy researchers who can work collaboratively with biologically oriented researchers in the treatment of late life mood disorders.

描述(由申请人提供)：这是一个职业中期导师奖的竞争性续展，该奖项最初名为“治疗患有CIND/aMCI的低收入老年人的抑郁”，现在名为社区环境中对晚年生活抑郁的战略性和可塑性干预。头衔的改变反映了我希望在接下来的五年职业生涯中进行的额外培训。在最初的奖项中，我研究了与轻度认知障碍相关的神经心理学和行为神经学。这一经历让我得以开发干预措施，解决心理治疗结果的认知调节因素，并指导下一代心理治疗研究人员，他们也对认知障碍和晚年情绪障碍的治疗感兴趣。该奖项产生了20篇论文和5份拨款申请(4份随后获得资助)，为我所在部门的初级教师制定了一个指导计划，并对加州大学旧金山分校的9名初级教师、加州大学系统外的3名教师和7名博士后研究员进行了个人指导。在这项建议中，我希望研究晚年抑郁症(LLD)的认知神经科学，并了解更多关于可塑性干预及其在LLD治疗中的潜在作用。我的目的不是改变我作为一名研究人员的身份，而是要对这两个广阔的领域有足够的了解，这样我就可以(1)将我从生物学理论中学到的东西与我已经拥有的关于LLD的心理学和社会学解释的知识结合起来，(2)与认知神经科学家和可塑性干预者合作，为LLD制定有针对性的行为干预措施，以及(3)将我在开发便携式和老年友好行为干预方面的专业知识添加到可塑性干预研究领域。我相信，这种培训将允许心理治疗和认知神经科学领域更好地相互促进，这将有助于改善心理健康研究方向。因为在我们这个领域，很少有科学家尝试从事这种类型的交叉受精，我计划也为博士后研究员开发一个培训课程，专注于行为干预研究和认知神经科学的交叉，以培养一代心理治疗研究人员，他们可以与以生物学为导向的研究人员合作，治疗晚年情绪障碍。

项目成果

The Use and Effectiveness of Mobile Apps for Depression: Results From a Fully Remote Clinical Trial.

• DOI: 10.2196/jmir.6482
• 发表时间: 2016-12-20
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Arean PA;Hallgren KA;Jordan JT;Gazzaley A;Atkins DC;Heagerty PJ;Anguera JA
• 通讯作者: Anguera JA

Does Cognition Predict Treatment Response and Remission in Psychotherapy for Late-Life Depression?

• DOI: 10.1016/j.jagp.2014.09.003
• 发表时间: 2015-02-01
• 期刊: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 7.2
• 作者: Beaudreau, Sherry A.;Rideaux, Tiffany;Arean, Patricia
• 通讯作者: Arean, Patricia

Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial.

通过使用治疗视频游戏技术来改善后期抑郁症和认知控制：概念验证随机试验。

• DOI: 10.1002/da.22588
• 发表时间: 2017-06
• 期刊: Depression and anxiety
• 影响因子: 7.4
• 作者: Anguera JA;Gunning FM;Areán PA
• 通讯作者: Areán PA

Corrigendum to 'Does Cognition Predict Treatment Response and Remission in Psychotherapy for Late-Life Depression?' [The American Journal of Geriatric Psychiatry 23 (2015) 215-219].

“认知能否预测晚年抑郁症心理治疗的治疗反应和缓解？”的勘误表

• DOI: 10.1016/j.jagp.2018.12.020
• 发表时间: 2019
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Beaudreau,SherryA;Rideaux,Tiffany;O'Hara,Ruth;Arean,Patricia
• 通讯作者: Arean,Patricia