2/2 Stepped, reward-exposure based therapy vs. PST in late life depression
2/2 阶梯式奖励暴露疗法与 PST 治疗晚年抑郁症的比较
基本信息
- 批准号:9251911
- 负责人:
- 金额:$ 28.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-11 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAlternative TherapiesBehavior TherapyBehavioralBiologicalBiologyCaringCharacteristicsClinicalClinical TrialsCollaborationsColorCommunitiesCompetenceDepressed moodDiseaseDisease remissionDoctor of MedicineDoctor of PhilosophyElderlyExecutive DysfunctionFemaleGenderGenerationsGeriatricsHamilton Rating Scale for DepressionHourInterventionMajor Depressive DisorderMedicalMental DepressionMental HealthMoodsMulticenter StudiesNeurobiologyNeurosciencesNursesOutcomeParticipantPatientsPersonsPharmacotherapyPhysical activityPoliciesPopulationProtocols documentationProviderPsychotherapyQuality of lifeRandomizedRecording of previous eventsRecruitment ActivityReportingResearchResourcesRewardsSample SizeScienceSelf EfficacyServicesSeveritiesSiteSocial WorkersStructureTechniquesTimeTrainingWorld Health OrganizationWorld Health Organization Disability Assessment Scheduleaging populationbasechronic depressioncommunity settingcomparative efficacycostdata managementdesigndisabilityeffective therapyemotion dysregulationevidence baseexperiencegeriatric depressionimprovednon-dementednovel therapeuticsolder patientpredictive modelingproblem solving therapyprogramspublic health relevanceresponseskillssocialtheoriestherapy developmenttreatment adherencetreatment response
项目摘要
DESCRIPTION (provided by applicant): Engage is a novel therapy for late life depression, a disorder that worsens the outcomes of most medical illnesses, promotes disability, increases expense, and complicates medical care by clouding the clinical picture and undermining treatment adherence. Late-life depression has a modest response to pharmacotherapy, and although problem-solving therapy (PST) was found efficacious, it is rarely utilized by community clinicians. Engage targets behavioral domains of late-life depression grounded on neurobiological constructs using behavioral strategies of known efficacy selected for their simplicity. "Reward exposure" is the principal treatment vehicle of Engage. The first 3 sessions consist of direct "reward exposure" but the therapists search for barriers in 3 behavioral domains, i.e. "negativity bias", "apathy", and "emotional dysregulation", and add strategies targeting these domains when needed. Engage uses a structured, stepped-care approach and makes personalization part of the treatment itself. The primary hypothesis of the study is that Engage is non-inferior to problem solving therapy (PST), a treatment with demonstrated efficacy in late life depression. Its secondary hypotheses postulate that Engage requires fewer training hours than PST, is non-inferior to PST in reducing disability and in inducing remission of depression. Exploratory analyses will focus on long-term efficacy of Engage (over 26 and 52 weeks) as well as mechanisms and predictors of its effects. The participants will be 300 (150 from each Center) older (>60 years) non-psychotic, non-demented persons with unipolar major depression who will be randomly assigned to 9 sessions of Engage or PST. We bring to this project two research groups with a history of a successful collaboration in 2 two-center R01 supported psychotherapy studies, complementary expertise in clinical biology, intervention development, clinical trials, and experience in directing multicenter studies. This application responds to two IOM reports, which predict that the workforce in geriatrics will be overwhelmed by the aging population, a problem that will reach cataclysmic proportions when the Affordable Care Programs come into being. Older adults seek services in community settings where the providers of initial care for depression are social workers and nurses without in-depth training in
psychotherapies. Engage is designed for such clinicians and, therefore, may have broad scalability (used by many professionals) and reach by offering to many depressed seniors access to effective psychotherapy. The stepped approach to personalization used by Engage may make it applicable to other populations.
描述(由申请人提供):Engage是一种针对晚年抑郁症的新疗法,这种疾病会使大多数医学疾病的结果恶化,促进残疾,增加费用,并通过模糊临床图景和破坏治疗依从性使医疗护理复杂化。老年抑郁症对药物治疗有适度的反应,尽管问题解决疗法(PST)被发现是有效的,但很少被社区临床医生使用。Engage的目标是基于神经生物学结构的老年抑郁症的行为领域,使用已知有效的行为策略,选择了它们的简单性。“奖励曝光”是Engage的主要治疗手段。前三个疗程包括直接的“奖励暴露”,但治疗师在三个行为领域寻找障碍,即;“消极偏见”、“冷漠”和“情绪失调”,并在需要时添加针对这些领域的策略。Engage采用结构化、阶梯式护理方法,并将个性化作为治疗本身的一部分。该研究的主要假设是,Engage不次于问题解决疗法(PST),一种已被证明对晚期抑郁症有效的治疗方法。它的次要假设假设Engage比PST需要更少的训练时间,在减少残疾和诱导抑郁缓解方面并不亚于PST。探索性分析将侧重于Engage的长期疗效(超过26周和52周)以及其作用的机制和预测因素。参与者将是300名(每个中心150名)年龄较大(60岁至60岁)的非精神病性、非痴呆的单相重度抑郁症患者,他们将被随机分配到9次Engage或PST。我们为这个项目带来了两个研究小组,他们在2个双中心R01支持的心理治疗研究中有成功的合作历史,在临床生物学、干预开发、临床试验方面有互补的专业知识,并在指导多中心研究方面有经验。该应用程序响应了两份IOM报告,这两份报告预测老年医学的劳动力将被人口老龄化所淹没,当平价医疗计划出现时,这个问题将达到灾难性的程度。老年人在社区环境中寻求服务,在社区环境中,提供抑郁症初步护理的是社会工作者和护士,没有受过深入的培训
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Patricia A. Arean其他文献
Patricia A. Arean的其他文献
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{{ truncateString('Patricia A. Arean', 18)}}的其他基金
Using Search Engine Data for Detection and Early Intervention in Suicide Prevention
使用搜索引擎数据进行自杀预防的检测和早期干预
- 批准号:
10401836 - 财政年份:2021
- 资助金额:
$ 28.35万 - 项目类别:
Using Search Engine Data for Detection and Early Intervention in Suicide Prevention
使用搜索引擎数据进行自杀预防的检测和早期干预
- 批准号:
10591819 - 财政年份:2021
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$ 28.35万 - 项目类别:
Using Search Engine Data for Detection and Early Intervention in Suicide Prevention
使用搜索引擎数据进行自杀预防的检测和早期干预
- 批准号:
10207109 - 财政年份:2021
- 资助金额:
$ 28.35万 - 项目类别:
UW ALACRITY Center for Psychosocial Interventions Research
华盛顿大学 ALACRITY 心理社会干预研究中心
- 批准号:
10167248 - 财政年份:2018
- 资助金额:
$ 28.35万 - 项目类别:
UW ALACRITY Center for Psychosocial Interventions Research
华盛顿大学 ALACRITY 心理社会干预研究中心
- 批准号:
9914127 - 财政年份:2018
- 资助金额:
$ 28.35万 - 项目类别:
Strategic and Plasticity Interventions for Late Life Depression in Community Settings
社区环境中晚年抑郁症的战略和可塑性干预措施
- 批准号:
9062712 - 财政年份:2015
- 资助金额:
$ 28.35万 - 项目类别:
2/2 Stepped, reward-exposure based therapy vs. PST in late life depression
2/2 阶梯式奖励暴露疗法与 PST 治疗晚年抑郁症的比较
- 批准号:
9462224 - 财政年份:2015
- 资助金额:
$ 28.35万 - 项目类别:
Strategic and Plasticity Interventions for Late Life Depression in Community Settings
社区环境中晚年抑郁症的战略和可塑性干预措施
- 批准号:
8996065 - 财政年份:2015
- 资助金额:
$ 28.35万 - 项目类别:
2/2 Stepped, reward-exposure based therapy vs. PST in late life depression
2/2 阶梯式奖励暴露疗法与 PST 治疗晚年抑郁症的比较
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9142355 - 财政年份:2015
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$ 28.35万 - 项目类别:
2/2 Stepped, reward-exposure based therapy vs. PST in late life depression
2/2 阶梯式奖励暴露疗法与 PST 治疗晚年抑郁症的比较
- 批准号:
8613178 - 财政年份:2014
- 资助金额:
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