Amplified Attention Training (AAT) for Age-related Cognitive Decline

描述(由申请者提供)：本项目的目标是修订第一阶段完成的针对年龄相关性认知下降的计算机化注意力训练计划(记忆道放大注意力训练，M-AAT)的原型，并进行一项多地点、随机、对照试验，以确定在这一人群中的有效性。作为一个群体，拥有 与年龄相关的认知下降往往具有较差的长期预后，并且比没有类似下降的个人更有可能需要管理性护理。我们最近的研究率先证明，以持续注意力和认知控制为目标的M-AAT可以产生持久的好处。当前项目的总体目标是衡量3个共同的主要结果：注意力、执行功能和功能能力。我们第一阶段试验的证据表明，M-AAT可以改善注意力和执行功能。在这个项目完成后，我们将有足够的结果数据提交FDA批准作为一种医疗设备，用于年龄相关性认知下降的认知增强(ICD-9代码R41.81)。

DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Memory Lane-Amplified Attention Training, M-AAT) designed for age-related cognitive decline completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, individuals with age-related cognitive decline tend to have poorer long-term prognosis and are more likely to require managed care than individuals without similar declines. Our recent studies are among the first to demonstrate that M-AAT, targeting sustained attention and cognitive control, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that M-AAT can improve attention and executive function. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in age-related cognitive decline (ICD-9 Code R41.81).