An Objective Snoring Index and its Association with Carotid Atherosclerosis

项目概述：候选人的总体长期目标是成为一名独立的调查员， 一项关于打鼾及其与心血管疾病和动脉粥样硬化的关系的研究计划。上 睡眠呼吸紊乱的严重程度是连续的，打鼾是睡眠呼吸紊乱的最轻微的一种。 阻塞性睡眠呼吸暂停综合征（OSA）是最严重的。 尽管OSA与 对于心/脑血管疾病，打鼾单独对健康结果的影响在很大程度上是未知的。此外，本发明还提供了一种方法， 大多数关于打鼾的研究都使用问卷来测量打鼾，强调一个客观的验证， 需要测量打鼾。 拟议研究的目标是（a）确定目标 打鼾指数与颈动脉粥样硬化最佳相关，独立于潜在的心血管疾病 混杂因素，在一项病例对照研究（K99期）和（B）中验证大样本中的独立关联 研究打鼾、阻塞性睡眠呼吸暂停综合征和肥胖之间的相互作用， 动脉粥样硬化（R 00期）。 我们有机会利用韩国基因组流行病学研究 （KoGES），一项正在进行的韩国中年和老年人队列研究，以实现研究目标。到 迄今为止，5，020名随机选择的参与者接受了两年一次的全面体检， 包括颈动脉内膜中层厚度和与心血管风险相关其他变量。在K99阶段， 我们将对100名非呼吸暂停打鼾者和100名年龄、体重指数和 来自KoGES的性别匹配的正常对照，使用便携式睡眠设备测量客观打鼾。 客观打鼾测量将包括（a）打鼾发作的频率，（B）打鼾的百分比，（c）打鼾的频率，（d）打鼾的频率，（e）打鼾的频率，（f）打鼾的频率，（g）打鼾的百分比，（ 打鼾时间在整个睡眠时间，和（c）打鼾声音强度。在R 00阶段，我们将 睡眠研究和评估打鼾的一个大型队列，将包括800名KoGES参与者， 打鼾的程度 使用现有的正在进行的大型队列，并提供有关参与者健康的全面数据 成果是实现拟议研究最终目标的低成本和非常创新的方法。 有一个实质性的基础设施，候选人将有机会获得多个其他元素，没有成本， 例如颈动脉IMT、生物标记物和用于未来遗传分析的DNA。 客观地测量打鼾， 家庭环境在方法上是创新的，将促进未来的打鼾和护理研究。给定 亚洲人口在美国迅速增长，这项研究将对亚洲人的健康具有重要意义。 美国人口中的亚洲人。 成功进行拟议的研究，并实现整体长期 职业目标，候选人将积极参加K99阶段的培训计划（a）睡眠- 相关呼吸障碍，包括打鼾~（B）颈动脉粥样硬化测量~（c）门诊技术 客观地测量打鼾~（d）科学写作，同行评审和传播~和（e）专业 在护理学校的教师职位的职业发展。

PROJECT SUMMARY: The candidate's overall long-term goal is to become an independent investigator with a program of research on snoring and its association with cardiovascular disease and atherosclerosis. On the continuum of severity of sleep-related breathing disorders, snoring is at the mildest end of the spectrum of which obstructive sleep apnea (OSA) is at the more severe end. Although OSA has been associated with cardio/cerebrovascular disease, effects of snoring alone on health outcomes are largely unknown. In addition, most studies on snoring have used questionnaires to measure snoring, emphasizing that an objective validated measurement of snoring is needed. The goals of the proposed research are (a) to determine the objective snoring index that is optimally associated with carotid atherosclerosis, independent of potential cardiovascular confounders, in a case-control study (K99 phase) and (b) to validate the independent association in a large cohort and examine interactions among snoring, OSA, and obesity that are strongly related to carotid atherosclerosis (R00 phase). We have the opportunity to use the Korean Genome Epidemiology Study (KoGES), an ongoing cohort study of Korean middle-aged and older adults, to achieve the research goals. To date, 5,020 randomly selected participants have undergone biennial comprehensive physical examinations that include carotid intima-media thickness and other variables related to cardiovascular risk. During the K99 phase, we will conduct home-based sleep studies for 100 non-apneic snorers and 100 age-, body-mass index-, and gender-matched normal-controls from the KoGES, to measure objective snoring using a portable sleep device. Objective snoring measurement will include (a) the frequency of snoring episodes, (b) the percentage of snoring time during whole sleeping hours, and (c) snoring sound intensity. During the R00 phase, we will do sleep studies and assess snoring in a large cohort that will consist of 800 KoGES participants with different degrees of snoring. Using an existing ongoing large cohort with comprehensive data on participants' health outcomes is a low-cost and very innovative approach to achieving the ultimate goal of the proposed study. There is a substantial infrastructure and the candidate will have access to multiple other elements at no cost, such as carotid IMT, biomarkers, and DNA for future genetic analyses. Measuring snoring objectively in the home environment is methodologically innovative and will facilitate future snoring and nursing research. Given that the Asian population is growing rapidly in the United States, this study will be significant for the health of Asians in the US population. To successfully conduct the proposed research and achieve overall long-term career goals, the candidate will actively participate in a training program during the K99 phase on (a) sleep- related breathing disorders, including snoring~ (b) carotid atherosclerosis measure~ (c) ambulatory technologies to objectively measure snoring~ (d) scientific writing, peer review, and disseminating~ and (e) professional development for career advancement into a faculty position in a nursing school.