Vermont Center on Behavior and Health

描述（由申请人提供）：这是一份修订后的申请，旨在支持在佛蒙特大学（UVM）建立行为与健康生物医学研究卓越中心（COBRE）。拟议中的中心将调查个人行为与慢性病和过早死亡风险之间的关系。不健康的个人行为（例如，药物滥用、缺乏身体活动）占美国每年过早死亡人数的40%，并大大增加了医疗保健成本和健康差距。目前迫切需要（a）对这些危险行为的脆弱性机制有更深入的科学了解，（B）采取更有效的干预措施来促进行为改变。我们将从行为经济学的概念框架来处理这些挑战。这项工作将涉及关键的跨学科合作（a）在UVM内的多个部门和学院，（B）与关键的佛蒙特州社区医疗保健领导者，以及（c）与其他大学，包括两个来自IDEA州（布朗大学和肯塔基州大学）。本提案的具体目标是：目标1：建立必要的核心，以发展和维持一个充满活力的跨学科研究卓越中心。这一目标的具体目标包括：（a）建立一个行政核心，提供领导、组织结构、知识基础设施、指导计划、财政管理以及COBRE供资以外的财政支助战略规划;（B）行为经济学和干预科学核心，支持干预发展和评估，成本效益的计量经济学建模，以及与健康相关的决策及其神经生物学基础的研究，以及（c）合作，传播和教育核心，以促进这些关键任务。目标2：支持优秀的初级/教师项目主任（PD）的选拔和职业发展，他们将成为中心的核心。PD及其研究主题是：（1）Robert Althoff，医学博士，博士，儿童失调，成人精神病理学和代谢障碍的共同机制;（2）Diann Gaalema，博士，改善低收入患者心脏康复参与的激励措施;（3）Julie菲利普斯，医学博士，针对超重/肥胖低收入妇女的肥胖体重增加的激励措施;（4）Kim Dittus，MD，PhD，超重乳腺癌幸存者减肥成功的预测因素;（5）Brian Sprague，PhD，行为，慢性病和原位导管癌后的生活质量。拟议中的中心将汇集一个跨学科小组的成就资深科学家，有前途的初级研究人员，以及杰出的顾问和合作者密切合作，建立一个卓越的临床研究领域的中心，这是至关重要的美国公共卫生。

DESCRIPTION (provided by applicant): This is a revised application for support to establish a Center for Biomedical Research Excellence (COBRE) in Behavior and Health at the University of Vermont (UVM). The proposed center will investigate relationships between personal behaviors and risk for chronic disease and premature death. Unhealthy personal behaviors (e.g., substance abuse, physical inactivity) account for 40% of premature deaths in the U.S. annually and substantially increase healthcare costs and health disparities. There is a tremendous need for (a) greater scientific understanding of the mechanisms underpinning vulnerability to these risk behaviors and (b) more effective interventions to promote behavior change. We will approach these challenges from a behavioral economics conceptual framework. This effort will involve key interdisciplinary collaborations (a) across multiple departments and colleges within UVM, (b) with key Vermont community healthcare leaders, and (c) with other universities, including two from IDeA states (Brown University and University of Kentucky). Specific Aims of this proposal are: Aim 1: Establish the cores necessary to develop and sustain a vibrant interdisciplinary center of research excellence. Goals of this aim include developing (a) an Administrative Core that provides leadership, organizational structure, intellectual infrastructure, a mentoring plan, fiscal management, and strategic planning for fiscal support beyond COBRE funding; (b) a Behavioral Economics and Intervention Sciences Core that supports intervention development and evaluation, econometric modeling of cost effectiveness, and the study of health-related decision making and its neurobiological underpinnings, and (c) a Collaboration, Dissemination, and Education Core to facilitate those key missions. Aim 2: Support the selection and career development of excellent junior\faculty Project Directors (PDs) who will become the nucleus of the center. The PDs and their research topics are: (1) Robert Althoff, MD, PhD, Shared Mechanisms in Child Dysregulation, Adult Psychopathology, and Metabolic Disorders; (2) Diann Gaalema, PhD, Incentives to Improve Cardiac Rehabilitation Participation in Low-income Patients; (3) Julie Phillips, MD, Incentives Targeting Gestational Weight Gain in Overweight/Obese Low-income Women; (4) Kim Dittus, MD, PhD, Predictors of Weight Loss Success in Overweight Breast Cancer Survivors; (5) Brian Sprague, PhD, Behaviors, Chronic Disease, and Quality of Life After Ductal Carcinoma In Situ. The proposed center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is vitall important to the U.S. public health.