HMS/CHB Center for Neuroscience Research

描述（由申请人提供）：在这个支持神经科学研究的机构中心核心赠款中，我们建议建立一个创新的神经成像中心，由四个核心设施组成，将为NINDS资助的哈佛医学院（HMS）和波士顿儿童医院（CHB）的研究人员提供服务。这些最先进的设施将为HMS和CHB神经科学界提供重要的新资源，并将提供单个实验室难以提供的基本服务。成像中心将由一个行政核心，一个高内容细胞成像核心，一个基于化学的阵列断层扫描核心和一个超分辨率成像核心组成。成像中心提供的实验机会和创新服务将使区域神经科学家获得独特的设备和几种新的尖端方法的培训，极大地受益于NINDS资助的研究人员在这些机构的研究计划。此外，该中心将作为共同努力的核心，加强HMS和CHB神经科学界之间的联系。因此，该中心的一个主要重点将是作为协作互动的纽带。为此，我们建议不仅要建立一套核心设施，而且要采取若干战略，减少广泛利用这些设施的障碍，包括提供关于核心方法的非正式教育和重要的技术支持。通过该中心的发展，我们希望从完全依赖以实验室为中心的研究转向更具成本效益和生产力的非凡核心的使用，同时进一步深化这两个充满活力的神经科学社区之间的现有联系。 相关性：我们建议建立一个神经成像中心，为NINDS资助的哈佛医学院和波士顿儿童医院的研究人员提供服务。这些设施将提供重要的新资源，并提供基本服务，这些服务对于单个实验室来说是困难和不切实际的，从而加快这些机构的神经科学研究步伐。

DESCRIPTION (provided by applicant): In this Institutional Center Core Grant to Support Neuroscience Research, we propose to establish an innovative Neural Imaging Center composed of four Core facilities that will serve NINDS-funded Harvard Medical School (HMS) and Children's Hospital Boston (CHB) investigators. These state-of-the-art facilities will provide important new resources to the HMS and CHB neuroscience community, and will perform essential services that are difficult and impractical for individual laboratories to provide on ther own. The Imaging Center will be composed of an Administrative Core, a High-Content Cellular Imaging Core, an immunohistochemistry-based Array Tomography Core, and a Super-resolution Imaging Core. The experimental opportunities and innovative services provided by the Imaging Center will give area neuroscientists access to unique equipment and training in several new cutting-edge methodologies, greatly benefiting the research programs of NINDS-funded investigators at these institutions. Moreover, the Center will function as the centerpiece of a concerted effort to strengthen ties between the neuroscience communities at HMS and CHB. Thus, a major focus of this Center will be to serve as a nexus for collaborative interactions. To this end, we propose not only to establish a set of core facilities, but also to adopt several strategies that reduce the barriers to their widespread utilization, including provisions for informal education regarding core methodologies and significant technical support. Through the development of this Center, we hope to shift from a complete reliance on individual laboratory-centered research to a more cost-effective and productive use of extraordinary cores while further deepening existing ties between these two vibrant neuroscience communities. RELEVANCE: We propose to establish a Neural Imaging Center to serve NINDS-funded Harvard Medical School and Children's Hospital Boston investigators. These facilities will provide important new resources and perform essential services that are difficult and impractical for individual laboratories to perform on their own, thereby accelerating the pace of neuroscience research at these institutions.