Mentoring Multidisciplinary Patient-Oriented Research in Viral Hepatitis

描述（由申请人提供）：Mandana Khalili博士是加州大学弗朗西斯科分校（UCSF）的医学副教授。她的长期职业目标是指导致力于以患者为导向的研究的早期临床研究人员，并成为努力提高我们对病毒性肝炎葡萄糖耐受不良发病机制的理解的领导者。她在此奖项期间的目标是扩大她在病毒性肝炎多学科临床和转化研究方面的研究和指导计划，从而增加最终成为成功的独立研究者的新研究者的人数。Khalili博士是一位成熟的研究者，具有丰富的指导经验， 致力于以患者为导向的研究，这从她进行高质量研究的能力和她的研究领导角色中可以看出。她的多学科临床和转化研究计划由正在进行的校外资助支持，将作为为初级研究人员提供指导的平台。她将利用UCSF丰富的学术环境及其临床研究培训资源，包括K30和K12职业发展计划以及临床和转化科学研究所，培训她的学员，使他们能够成功竞争以患者为导向的研究中的导师职业发展奖，并过渡到独立的临床研究者。美国国立卫生研究院已将丙型肝炎感染（美国肝病最常见的原因）和糖尿病的病理生理学、治疗和预防确定为健康研究的高优先领域。Khalili博士的研究目标是继续对病毒性肝炎及其并发症进行临床研究，以深入了解丙型肝炎与胰岛素作用之间的关系以及疾病发病机制中的宿主和病毒相互作用。该研究计划将为新的和初级临床研究人员提供指导和研究培训机会， 疾病的相互作用，以及进行胰岛素抵抗和胰岛素分泌的最先进的生理测量。此外，她正在进行的研究活动的资源将支持学员在病毒性肝炎中进行以患者为导向的研究。该奖项提供的受保护的时间将使她能够保持生产力并实现她的导师和研究目标。

DESCRIPTION (provided by applicant): Dr. Mandana Khalili is an Associate Professor of Medicine at the University of California, San Francisco (UCSF). Her long-term career objectives are to mentor early clinical investigators committed to patient-oriented research and to become a leader in efforts to improve our understanding of the pathogenesis of glucose intolerance in viral hepatitis. Her objectives during this award are to expand her research and mentoring program in multidisciplinary clinical and translational research in viral hepatitis, thereby increasing the pool of new investigators who ultimately become successful independent investigators. Dr. Khalili is an established investigator with significant mentoring experience who is committed to patient- oriented research, as evidenced by her ability to conduct high-quality research and her research leadership roles. Her multidisciplinary clinical and translational research program supported by ongoing extramural funding will serve as the platform for providing mentorship for junior investigators. She will capitalize on the rich academic environment of UCSF and its clinical research training resources, including K30 and K12 career development programs and the Clinical and Translational Sciences Institute to train her mentees to enable them to compete successfully for mentored career development awards in patient-oriented research and their transition to independence as clinical investigators. The pathophysiology, treatment, and prevention of both hepatitis C infection - the most common cause of liver disease in United States - and diabetes have been identified by the National Institutes of Health as high- priority areas of health research. Dr. Khalili's research goals are t continue to conduct clinical investigation in viral hepatitis and its complications that will provie insight into the relationship between hepatitis C and insulin action as well as host and viral interactions in disease pathogenesis. This research plan will provide mentoring and research training opportunities for new and junior clinical investigators in predictive modeling, in complex disease interactions, and in performing state-of-the-art physiologic measurements of insulin resistance and insulin secretion. In addition, the resources from her ongoing research activities will support mentees in performing patient-oriented research in viral hepatitis. The protected time afforded by this award will allow her to maintain her productivity and to achieve her mentorship and research goals.