University of Hawaii Cancer Center CCSG

描述(由申请者提供)：本申请旨在为夏威夷大学癌症中心(UHCC)、夏威夷州和太平洋地区唯一开展癌症研究的机构寻求CCSG的新资金。作为世界上存在显著健康差距的地区的前哨，UCC在将尖端的基础、翻译和临床研究带到独特的地区人口能够接触到的如何预防和治疗癌症方面发挥着至关重要的作用。该联盟是新成立的夏威夷癌症联盟的一部分，同时也是夏威夷三大医院系统的一部分。该联盟使联盟能够开发新的临床计划，并扩大其临床和转化性研究，以开发新的诊断和治疗方法。到2017年，美国肝细胞癌机构已承诺每年向大学肝细胞癌提供220万美元，大学肝细胞癌从NCI获得2320万美元，从其他同行审查来源获得1800万美元，总计4120万美元的同行审查赠款资金。UCC/CC最近招聘了一名新主任，以及30名额外的教职员工，他们带来了广泛的科学和临床技能。这些新成员帮助UCC/HCC继续建立和加强其基础科学基础，并极大地提高了其加速临床和转化性癌症研究的能力。为了加强他们的跨学科和转化性研究，三个研究计划(癌症生物学、癌症流行病学和癌症预防和控制)进行了重组，以便在各自的研究领域提供更好的重点。UCC的所有项目都由新主任领导，每个主任都致力于增加他们项目的活力和互动性。此外，规划和评估还包括 进行了结构调整，为调查人员创造了更多互动机会，并与合作机会保持同步。此应用程序请求支持7个共享资源(分析生物化学、生物统计和信息学、基因组学、显微镜和成像、营养支持、病理学以及临床和转译研究服务)，以及一个正在开发的共享资源(动物癌症发生)。研究设施的主要增加包括2012年开业的一座新的150,000平方英尺的UCC研究大楼，该大楼将共同容纳我们不断增长的教师，因为夏威夷大学已经为UCC批准了总共18个新的终身教职跟踪职位。这项应用描述了在基础和转化型癌症研究方面的持续卓越，并极大地加强了临床研究的领导地位和基础设施。

DESCRIPTION (provided by applicant): This application seeks renewed CCSG funding for the University of Hawai'i Cancer Center (UHCC), the state of Hawai'i and the Pacific Region's only institution where cancer research is performed. As an outpost in an area of the world with significant health disparities, UHCC serves a critical function in bringing cutting edge basic, translational, and clinical research on how to prevent and treat cancer within reach of the unique regional population. UHCC is part of the new Hawai'i Cancer Consortium (HCC) along with the 3 major hospital systems of Hawai'i. This consortium enables UHCC to develop a new clinical program and expand its clinical and translational research towards the development of new diagnostics and therapies. HCC institutions have committed $2.2 million annually towards UHCC through 2017, and UHCC receives $23.2M from the NCI and $18M from other peer-reviewed sources for a total of $41.2M in overall peer-reviewed grant funding. UHCC/HCC has recently recruited a new Director, along with 30 additional faculty members, who bring with them a broad-spectrum of scientific and clinical skills. These new recruits have helped UHCC/HCC continue to build and strengthen its basic-science foundations and to greatly enhance its ability to accelerate clinical and translational cancer research. To enhance their transdisciplinary and translational research, the three Research Programs (Cancer Biology, Cancer Epidemiology, and Cancer Prevention and Control) have been reorganized to provide a better focus in their areas of research. All Programs at UHCC are led by new Directors, each dedicated to increasing the vitality and interaction of their Programs. In addition, Planning and Evaluation has been restructured to create more opportunities for investigators to interact and stay abreast of opportunities for collaboration. This application requests support for 7 Shared Resources (Analytical Biochemistry, Biostatistics and Informatics, Genomics, Microscopy and Imaging, Nutrition Support, Pathology, and Clinical and Translational Research Services), and one developing Shared Resource (Animal Carcinogenesis). Major additions in research facilities include a new 150,000-sq ft UHCC research building opening in 2012 that will collectively house our growing faculty, as the University of Hawai'i has approved a total of 18 new tenure track positions for UHCC. This application describes continued excellence in basic and translational cancer research, and greatly strengthened clinical research leadership and infrastructure.