Analytical Biochemistry Shared Resource

分析生物化学共享资源

• 批准号: 8369394
• 负责人: MICHELE CARBONE
• 金额: $ 10.69万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8369394
• 关键词: Analytical Biochemistry; Analytical Chemistry; Biological Assay; Cancer Center; Cancer Center Support Grant; Chemicals; Clinical Markers; Collaborations; Computers; Consultations; Custom; Data; Equipment; Feedback; Floor; Funding; Future; Grant; Growth; Hawaii; Hazardous Substances; Human Resources; Immunoassay; Institutes; Laboratories; Laboratory Technicians; Malignant Neoplasms; Mass Spectrum Analysis; Methods; Molecular; Monitor; Peer Review; Productivity; Protocols documentation; Publications; Regulation; Research Activity; Research Personnel; Resource Sharing; Resources; Robin bird; Safety; Services; Speed; Techniques; Technology; Testing; Universities; Update; anticancer research; base; cost; cost effective; design; flexibility; improved; instrumentation; liquid chromatography mass spectrometry; member; programs; quality assurance; small molecule; square foot

This facility, operating since 1990, provides cost-effective and accurate chemical analyses for molecules relevant to cancer research of Cancer Center (CC) investigators. It is also a base for consultation related to the quantitation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LCMS) and multiplexed immunoassays. In addition, routine analyses and determinations of clinical markers are offered to investigators. A host of new assays have been implemented in the current cycle due to needs of CC members. No other laboratories are available to provide many of these services in the State of Hawai'i, particularly regarding type, speed, cost, and combinations of assays, many of which are custom designed by this core to fulfill the specific requirements of CC projects. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this core provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides cost effective service to CC investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming years. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth: its productivity increased by 84% since the last cycle and has grown accordingly in personnel and revenue. The great value of this core is underscored by a total of 79 cancer related peer reviewed publications during FY06-11 that involved services by the ABSR (58% inter-programmatic, 13% intra-programmatic).

该设施自1990年开始运营，为癌症中心（CC）研究人员的癌症研究相关分子提供具有成本效益和准确的化学分析。它也是与分析化学中分析物的定量和策略相关的咨询基础。提供先进方法的服务和专业知识，包括最先进的技术，特别是液相色谱质谱（LCMS）和多重免疫测定。此外，还向研究者提供临床标志物的常规分析和测定。由于CC成员的需求，在当前周期内实施了一系列新的检测。在夏威夷州，没有其他实验室可以提供这些服务，特别是关于检测的类型、速度、成本和组合，其中许多是由该核心定制设计的，以满足CC项目的特定要求。通过参加内部和外部质量保证计划，包括参加国家标准和技术研究所组织的循环测试，不断监测服务的高质量。该核心的可用性提供了最先进的服务，改善了对研究者的反馈，促进了跨学科合作，并为CC研究者提供了具有成本效益的服务。目前的满负荷使用预计将在可预见的未来继续下去。需要该资源提供服务的新供资项目将超过今后几年终止的项目。在本周期内通过支助小组支助赠款获得的设备大大提高了这一资源的潜力。该工厂取得了显著的增长：自上一个周期以来，其生产率提高了84%，人员和收入也相应增长。在2006 - 2011财年期间，共有79篇癌症相关同行评审出版物涉及ABSR的服务（58%是跨项目的，13%是项目内的），这一核心的巨大价值得到了强调。