Analytical Biochemistry Shared Resource

该设施自1990年投入使用，为癌症中心(CC)研究人员的癌症研究相关分子提供经济高效和准确的化学分析。它也是与分析化学中分析物的定量和策略相关的咨询的基础。提供先进方法的服务和专业知识，包括最先进的技术，特别是液-色质谱(LC-MS)和多重免疫分析。此外，还为研究人员提供了临床标志物的常规分析和测定。由于CC成员的需要，在本周期内实施了许多新的化验方法。夏威夷没有其他实验室可以提供其中的许多服务，特别是在类型、速度、成本和分析组合方面，其中许多是由该核心定制设计的，以满足CC项目的特定要求。通过参加内部和外部质量保证计划，包括参加由国家标准与技术研究所组织的循环测试，持续监测高质量的服务。这一核心的提供提供了最先进的服务，改善了对调查人员的反馈，促进了跨学科合作，并为CC调查人员提供了具有成本效益的服务。预计在可预见的未来，目前的满负荷使用将继续下去。需要资源服务的新资助项目的数量将超过未来几年终止的项目数量。本周期通过CCSG支助赠款获得的设备极大地增强了这一资源的潜力。这一设施显示出显著的增长：自上一个周期以来，其生产率提高了84%，人员和收入也相应增加。这一核心的巨大价值在06-11财年期间总共79篇与癌症相关的同行审查出版物中得到了强调，这些出版物涉及ABSR的服务(58%是方案间的，13%是方案内的)。

This facility, operating since 1990, provides cost-effective and accurate chemical analyses for molecules relevant to cancer research of Cancer Center (CC) investigators. It is also a base for consultation related to the quantitation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LCMS) and multiplexed immunoassays. In addition, routine analyses and determinations of clinical markers are offered to investigators. A host of new assays have been implemented in the current cycle due to needs of CC members. No other laboratories are available to provide many of these services in the State of Hawai'i, particularly regarding type, speed, cost, and combinations of assays, many of which are custom designed by this core to fulfill the specific requirements of CC projects. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this core provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides cost effective service to CC investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming years. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth: its productivity increased by 84% since the last cycle and has grown accordingly in personnel and revenue. The great value of this core is underscored by a total of 79 cancer related peer reviewed publications during FY06-11 that involved services by the ABSR (58% inter-programmatic, 13% intra-programmatic).