Educating Physician-Neuroscientists: The R25 at UCSF

项目摘要/摘要 内科科学家短缺，选择进入研究职业的内科医生数量为 正在衰退。这种短缺威胁着生物医学研究企业，而此时 医生-神经科学家将做出实质性发现，有助于理解和治疗 神经系统疾病(如阿尔茨海默病、中风、癫痫、帕金森病)有所增加 美国国家卫生研究院(NIH)制定了一份路线图，鼓励以疾病为导向 在支持性学术环境中进行研究，包括特别强调提高研究的成功率 医生-科学家的培训方案2 目前医生-科学家队伍下降的一个原因是需要很长的培训时间来 实现研究自主性。首次接受NIH R 01拨款的平均年龄(一种常用的 研究独立性的衡量标准)对于在以下方面面临独特挑战的MD申请者来说已达到43岁 走向研究独立的道路。当医生完成临床住院医师培训并 准备申请职业发展资金的许多人已经快30岁了。这段时间的标志是 重要的生活方式决定(例如，组建家庭、经济独立、购买第一套住房) 和职业发展决策。加上年末平均约150,000美元的债务 医学院，这些经济和生活方式的因素结合在一起，阻碍了潜在的内科科学家 从事与低收入、低资助率和几乎没有长期目标相关的研究职业 保安。其他职业途径(如私人执业、行业)对许多人来说似乎更有吸引力 正在接受培训的最聪明的医生。 R25研究教育计划通过在NINDS提供新的 通过改进培训、指导和支持性研究来协助有前途的内科研究人员的资源 最大限度地提高培训成功过渡的可能性的环境和资源 环境对独立研究事业的影响。神经科、神经外科和放射科 在加州大学旧金山分校(UCSF)，他们致力于解决下降的问题 通过鼓励住院医生在研究期间发展或扩展研究追求，对研究职业产生兴趣 临床培训年限。加州大学旧金山分校的神经科处于有利地位，可以作为主要的 临床神经科学研究教育项目的赞助商，详细说明如下，这是本次会议的重点。 申请。

Project Summary/Abstract There is a shortage of physician scientists and the number of physicians choosing to enter research careers is declining. This shortage threatens the biomedical research enterprise at a time when the opportunities for physician-neuroscientists to make substantial discoveries contributing to understanding and treatment of nervous system diseases (e.g.-Alzheimer disease, stroke, epilepsy, Parkinson disease) have increased dramatically.1 The National Institute of Health (NIH) has developed a roadmap to encourage disease-oriented research in supportive academic environments, including a special emphasis on improving the success rate of training programs for physician-scientists.2 One reason for the current decline in the physician-scientist pipeline is the long training period required to reach research independence. The average age of a first-time NIH R 01 grant recipient (one commonly used measure of research independence) has reached 43 years for MD applicants who face unique challenges on the path to research independence. By the time physicians have completed clinical residency training and are ready to apply for career development funding, many have reached their late 30s. This period is marked by important lifestyle decisions (e.g.-having a family, becoming financially independent, purchasing a first home) and career development decisions. Coupled with an average debt of approximately $150,000 at the end of medical school, these financial and lifestyle factors combine to discourage potential physician-scientists from embarking on research careers associated with low income, low rates of grant funding, and little long term security. Other career avenues (e.g.-private practice, industry) may seem more attractive for many of the brightest physicians in training. The R25 research education program implements the vision of the NIH roadmap at NINDS by providing new resources to assist promising physician investigators with improved training, mentorship, a supportive research environment, and resources that maximize the probability of a successful transition from the training environment to independent research careers. The Departments of Neurology, Neurosurgery, and Radiology at the University of California, San Francisco (UCSF) are committed to addressing the problem of declining interest in research careers by encouraging residents to develop or extend investigative pursuits during the clinical training years. The Department of Neurology at UCSF is well positioned to serve as the primary sponsor of the clinical neuroscience research education program, detailed below, that is the focus of this application.