Administration

杰克逊实验室癌症中心（JAXCC）正在经历一个深刻的扩大其成员，由新的癌症为重点的领导和开放的JAX基因组医学校园的驱动。结合JAX哺乳动物遗传学（巴尔港）项目的振兴，JAX将使以癌症为重点的教师增加两倍以上。自2012年1月刘博士成为JAXCC主任以来，招募了八名新成员，这表明了这一计划的可行性。JAXCC的新成员为癌症中心带来了新的癌症研究和技术专长以及强大的转化研究能力。在今后五年内，机构对这些新调查员的承诺估计为1 900万美元。 发展资金是确保JAXCC持续增长和生产力的关键因素。在上一个赠款周期，新的调查资金被用来支持七名初级教师。需要资金为新调查员提供部分支助，这将通过机构承付大量资金来实现。该战略计划要求在今后五年内再征聘8名JAXCC成员，机构承诺估计为2 200万美元。癌症中心招募的总体目标是与内部和外部咨询委员会协商确定的，包括：1）扩大对癌症系统生物学和癌症基因组学的关注; 2）参与转化科学，包括癌症药理学/系统药理学，化学生物学和分子病理学，以丰富基础科学重点; 3）战略性地招募将加强癌症正交方法的教师，如系统计算生物学和衰老方面的专家。其结果将是一个癌症的重点，包括研究重点是人类遗传学和基因组学在康涅狄格州，紧密结合小鼠基因组学专业知识在缅因州，以模拟人类癌症基因组的复杂性。 试点项目计划是实现JAXCC战略目标的计划的重要组成部分。项目的授予是基于科学的质量，他们对一个或多个战略目标的预期贡献，以及为成熟项目争取联邦资金的计划，特别是来自NCI的资金。在上一个赠款周期，12项提案获得资助，包括2012年以来的9项提案。CCSG（156 556美元）和机构（367 645美元）资金支持了该项目。总的来说，资助的项目支持9个JAXCC成员和8个外部机构之间的合作。已出版了一份出版物，另有三份正在编写中。迄今为止，已向同行审查机构提交了基于这些试点项目的9项赠款提案; 2项已获批准，3项正在审查中。 要求增加资金用于扩大试点项目方案，至少与机构资金一对一匹配。开发转化技术的项目将使基础科学产生临床影响，这些项目具有特别的优先权。加强了对该计划的监督。科学执行委员会（SEC）确定年度提案征集的优先事项，与申请人合作完善实现战略目标的研究计划，批准奖项，并为项目的持续时间提供科学指导。Tennent博士是研究管理副主任，负责监测每个试点项目朝着既定里程碑的进展情况，并跟踪由此产生的资助和手稿提交情况。

The Jackson Laboratory Cancer Center (JAXCC) is undergoing a profound expansion of its membership, driven by new cancer-focused leadership and the opening ofthe JAX Genomic Medicine campus. Combined with the revitalization of the program at JAX Mammalian Genetics (Bar Harbor), the JAX will more than triple the cancer-focused faculty. The recruitment of eight new members since January 2012, when Dr. Liu became the JAXCC Director demonstrates the feasibility of this plan. The new JAXCC members bring new cancer research and technological expertise and a strong translational research capability to the Cancer Center. Institutional commitment to these new investigators is estimated at $19 million over the next five years. Developmental funds are a crucial factor in assuring the JAXCC's continued growth and productivity. In the previous grant cycle, new investigator funds were used to support seven junior faculty members. Funds are requested for partial support of new investigators, which will be leveraged by significant institutional commitment of funds. The strategic plan calls for the recruitment of 8 additional JAXCC members over the next 5 years, with institutional commitment estimated at $22 million. The overall goals in recruiting to the Cancer Center, determined in consultation with internal and external advisory committees include: 1) expanding the focus on cancer systems biology and cancer genomics; 2) engaging translational sciences that include cancer pharmacology/systems pharmacology, chemical biology, and molecular pathology to enrich the basic science focus; and 3) strategically recruiting faculty who will strengthen orthogonal approaches to cancer, such as experts in systems computational biology, and aging. The result will be a cancer focus that comprises research focused on human genetics and genomics in Connecticut, tightly integrated with mouse genomics expertise in Maine to model the complexity of the human cancer genome. The pilot project program is an essential part of the plan to achieve the JAXCC's strategic goals. Projects are awarded based on the quality ofthe science, their anticipated contribution to one or more strategic goals, and the plan for securing federal funding, especially from NCI, for the mature project. In the previous grant cycle, 12 proposals were funded, including 9 since 2012. CCSG ($156,556) and institutional ($367,645) funds supported the project. In total, the funded projects support collaborations among 9 JAXCC members and 8 external institutions. One publication has resulted and three are in preparation. Nine grant proposals based on those pilots have been submitted to peer-reviewed agencies to date; 2 were awarded, and 3 are under review. An increase in funds is requested for expansion of the pilot project program, with at least a one to one match from institutional funds. Projects that develop translational technologies that will move basic science to clinical impact are of special priority. Oversight ofthe program has been strengthened. The Scientific Executive Committee (SEC) sets the priorities for the annual proposal solicitation, works with applicants to refine a research plan that achieves the strategic goal(s), approves awards, and provides scientific guidance for the project's duration. Dr. Tennent, Associate Director for Research Administration, monitors progress of each pilot toward stated milestones and tracks resulting grant and manuscript submissions.