qHTS to Identify Activators of BRCA1 Expression

项目亮点：完成了初级筛选，并针对多种二级分析进一步筛选命中点，以表征活性。目前正在进行先进的基于细胞的分析，以确定进一步开发的关键系列。

Project highlights: the primary screen was completed, and hits were further screened against a diverse panel of secondary assays to characterize activity. Advanced cell-based assays are currently underway to identify key series for further development. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.