Frontiers in Stem Cells and Regeneration Course

描述（由申请人提供）：多能干细胞和再生医学是迅速兴起的领域，在NIH的临床、转化、生物医学和行为投资组合的整个范围内具有巨大的生物医学意义。这项新的R25申请为我们的高级培训课程寻求五年的赞助，该课程名为：干细胞和再生前沿（FrSCR），每年在伍兹霍尔的MBL举行，由Jennifer Morgan （MBL）和Gerald Schatten（匹兹堡）共同主持。FrSCR是由我们目前资助的U13奖发展而来的，过去几年我们在伍兹霍尔成功地提供了U13奖。FrSCR建立在现有课程的显著优势和成功的基础上，同时扩展到纳入新兴的，重要的生物医学概念和再生和多能性方面的复杂技术突破。本课程使学员能够在多能干细胞（PSC）和再生医学领域开始成功的研究项目，包括多能成体干细胞（ASC）。我们为学员提供必要的实验室技术知识，职业指导和PSC研究的道德法律社会影响（ELSI），以大大提高他们成功进入这一领域。为实现这一目标，我们提出以下具体目标：提供关于干细胞和再生的基本概念的深入指导。2. 使用尖端技术，提供干细胞和再生实验的详细方法的实践培训。3. 培训学员了解该领域的开放性问题，以及如何利用干细胞和再生生物学来解决与人类发育和生殖障碍有关的问题。4. 提供职业规划和晋升的机会，并对学员进行再生医学研究的法律、伦理和监管方面的教育。5. 营造学院式的国际化环境，为学生提供长期互动和合作的交流机会。FrSCR是一个充满活力和不断发展的实体，每年都会提供一系列关于新兴概念的新鲜日常讲座，随后是为期一周的扩展讨论，实验室研究，技术密集的讲习班和非正式研讨会。本课程面向致力于基础研究、转化研究或最终临床研究的既有研究人员、高级研究员和新独立的科学家。本课程将讨论当前的主要问题，然后进行批判性的讨论和实验室实验，其中介绍了先进的新技术来探索这些问题。因此，本课程将通过培训新的研究人员为生物医学研究提供显著的好处

DESCRIPTION (provided by applicant): Pluripotent stem cells and regenerative medicine are rapidly emerging fields with enormous biomedical implications across the entire spectrum of NIH's clinical, translational, biomedical and behavioral portfolios. This new R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Stem Cells and Regeneration (FrSCR) held annually at the MBL in Woods Hole under the Co-Directorship of Jennifer Morgan (MBL) and Gerald Schatten (Pittsburgh). FrSCR developed from our currently funded U13 award, which we offered successfully at Woods Hole during the past years. FrSCR builds on the significant strengths and successes of the existing course, while expanded to incorporate emerging, important biomedical concepts and sophisticated technological breakthroughs in regeneration and pluripotency. This course enables participating trainees to start successful research programs in the fields of pluripotent stem cells (PSC) and regenerative medicine, including multipotent adult stem cells (ASC). We provide trainees the necessary knowledge of laboratory techniques, career mentoring and ethical legal societal impact (ELSI) of PSC research to greatly enhance their successful entry into this field. In order to achieve this goal, we propose the following specific aims: 1. To provide in-depth instruction on the fundamental concepts in stem cells and regeneration. 2. To provide hands-on training in the detailed methods for experimentation with stem cells and regeneration, using cutting-edge techniques. 3. To educate trainees on the open questions in the field, and how stem cells and regenerative biology can be used to solve problems related to human developmental and reproductive disorders. 4. To provide opportunities for career planning and advancement, and to educate trainees on the legal, ethical, and regulatory landscape in which regenerative medicine research occurs. 5. To foster a collegial, international environment, and to provide students with networking opportunities that lead to long-term interactions and collaborations. FrSCR is a dynamic and evolving entity that each year offers a fresh series of daily lectures on emerging concepts, followed by extended discussions, laboratory research, technologically intense workshops and informal seminars over a week-long period. The course is directed towards established investigators as well as advanced fellows and newly independent scientists who are committed to fundamental, translational or eventual clinical research studies. The course addresses major current problems, followed by critical discussions and laboratory experiments in which advanced new techniques are presented to explore these problems. Thus, this course will provide a significant benefit to biomedical research through the training of new investigators in the field of stem cells and regeneration.