IHVN H3 Africa Biorepository Initiative

描述（由申请人提供）：位于尼日利亚人类病毒学研究所（IHVN）的非洲微生物组和基因组学研究合作中心（ACCME）由非洲科学家Clement Adebamowo博士领导，他曾担任非洲第一阶段HapMap项目的首席研究员，不仅是非洲大陆基因组研究的先驱，也是解决非洲大陆基因组研究伦理挑战的先驱。ACCME生物储存库由Alash'le Abimiku博士领导，他是一位经验丰富的非洲实验室科学家，在非洲拥有20年的研究和储存库经验，也是本提案的首席研究员。第一阶段实施的目标是：提高ACCME生物资源库的能力，以实现第二阶段实施所需的国际生物和环境资源库协会（ISBER）最佳实践。为了实现第一阶段的目标，ACCME生物库与科里尔研究所合作实现了三个具体目标：1)评估当前的实践并确定优势和差距；2)升级存储库实践和基础架构；3)进行第二期试点实施。这个为期两年的第一阶段过程在IHVN经验丰富的非洲科学家和技术人员与来自科里尔研究所的同行之间进行了基于质量评估的迭代互动，后者提供客观评估、互动教学和指导能力建设，以借鉴科里尔已证实的模型，为第二阶段实施灌输ISBER最佳实践。第二阶段的目标是：扩大ACCME生物储存库的能力，以支持多个h3非洲研究人员在非洲开展高质量的基因组学和转化研究，使用h3非洲和更大的研究界可以获得的经过良好处理、保存和质量控制的、冗余保护的人类生物样本。为实现ACCME生物库的5年二期目标，ACCME生物库有5个具体目标：1)建立一个高质量的人类原始生物样本生物库；2)开发、实施、管理和支持强大的基于云计算的生物信息学工具，以支持生物库容量；3)建立行政管理和质量保证/质量控制（QA/QC）程序和可持续的资助策略；4)对员工进行生物库和生物银行科学的短期、中期和长期培训和指导；5)整合生物银行和生物库伦理的最佳实践。这一5年计划分阶段扩大人员配备和基础设施，通过提供可靠的样本处理支持、安全运输、快速获取和记录样本质量、关于临床和流行病学数据以及样本数量和质量的可获取信息、可靠的检索和积极促进合作，以实现最佳科学和可持续实践和供资，从而支持多个非洲基因组研究伙伴。对可靠的存储库功能的持续质量改进和最终用户的持续反馈促进了对服务交付和产品质量的信任。

DESCRIPTION (provided by applicant): The African Collaborative Center for Microbiome and Genomics Research (ACCME), based at the Institute of Human Virology-Nigeria (IHVN) is led by Dr. Clement Adebamowo the African scientist who served as the Principal Investigator of the African Phase I HapMap Project and is a pioneering leader not only in genomic research on the African Continent but also in addressing the ethical challenges of genomic research on the Continent. The ACCME Biorepository is directed by Dr. Alash'le Abimiku, a highly experienced African laboratory scientist with two decades of research and repository experience in Africa, and the Principal Investigator of the current proposal. The goal of Phase I implementation is to: Advance the capacity of the ACCME Biorepository to achieve International Society for Biological and Environmental Repositories (ISBER) best practices required for Phase II implementation. To achieve the Phase I goal the ACCME Biorepository partners with the Coriell Institute to implement three Specific Aims: 1) Assessment of current practice and identify strengths and gaps; 2) Upgrade repository practice and infrastructure; 3) Conduct pilot Phase II implementation. This two-year Phase I process engages an iterative quality assessment-based interaction between experienced African scientists and technicians at IHVN and their counterparts from Coriell Institute who provide objective assessment, interactive didactic and mentored capacity building to instill ISBER best practices for Phase II implementation drawing upon Coriell proven models. The goal of Phase II is to: Expand the capacity of the ACCME Biorepository to support multiple H3Africa investigators to conduct high quality genomics and translational research in Africa using well processed, preserved and quality controlled and redundantly protected human biological samples accessible to the H3Africa and larger research community. To achieve the 5-year Phase II goals the ACCME Biorepository targets 5 Specific Aims: 1) Implement a high quality biorepository of primary human biologic samples; 2) Develop, implement, manage and support robust cloud computing based bioinformatics tool to support biorepository capacity; 3) Establish administrative governance and Quality Assurance/Quality Control (QA/QC) procedures and sustainable funding strategies; 4) Conduct short, medium and long term training and mentoring of staff on Biorepository and Biobanking Sciences; 5) Integrate best practices in biobanking and biorepository ethics. This 5-year plan implements a staged expansion of staffing and infrastructure to support multiple African genomic research partners by providing reliable sample processing support, secure shipping, rapid accession and documentation of sample quality, accessible information on clinical and epidemiological data and sample quantity and quality, reliable retrieval and proactive facilitation of collaboration to achieve best science and sustainable practice and funding. Continuous quality improvement for reliable repository function and ongoing feedback from end users fosters trust in service delivery and product quality.