Murine GI Surgical Modeling Core

GI外科建模核心提供独特的鼠类外科服务（减肥和其他新型外科手术）。建立这一核心是为了加强VDDRC调查人员的调查工作，并提供否则不可行的研究途径。核心的主要理由在于越来越多的小鼠具有与消化系统疾病相关或潜在相关的遗传改变，以及需要研究遗传（或药理学）操作影响所必需的手术和实验技术。为了研究健康、无压力的小鼠，这些程序需要技巧和实践。该核心拥有熟练的外科医生，能够适应一系列手术，以满足VDDRC成员的特定需求，包括减肥手术，巴雷特食管和肝移植手术模型和缺血/再灌注损伤模型。使用手术模型获得的结果的质量与动物的一般健康状况直接相关。核心已经非常重视提供没有可避免的、不希望的并发症的鼠模型。术前和术后护理对于手术的成功与手术本身一样重要。核心的总体目标是提供减肥手术的小鼠模型，使用旨在反映人类，肝移植和适应VDDRC成员需求的独特定制手术模型的程序。为实现这一目标，核心是： 1.提供小鼠减肥手术模型及其在基础和转化研究中的应用。 2.提供Barrett食管、肝脏和小肠移植的小鼠模型。 3.提供围手术期护理，以确保动物健康，没有过度的压力。 4.培训研究人员进行专门的外科手术。 5.通过制定新的程序来满足VDDRC调查员的需求。 核心与其他VDDRC核心，小鼠代谢表型中心（MMPC），糖尿病研究和培训中心以及动物护理部门密切互动，以确保并最大限度地有效利用资源和人员，并加强跨学科合作。

The GI Surgical Modeling Core provides unique murine surgical services (bariatric and other novel surgical procedures). This core was established to enhance the investigative efforts of the VDDRC investigators and provide avenues of research that otherwise would not be feasible. The primary rational for the core rests in the growing number of mice having genetic alterations with relevance or potential relevance to digestive diseases and the need for surgical and experimental techniques that are necessary to study the impact of genetic (or pharmacologic) manipulations. The procedures require skill and practice in order to study healthy, unstressed mice. The core has skilled surgeons that are capable of adapting a range of procedures to suit specific needs of VDDRC members including bariatric surgical procedures, surgical models for Barrett's esophagus and liver transplantation and ischemia/reperfusion injury models. The quality of the results that are obtained using surgical models is directly related to the general health of the animal. The Core has placed significant emphasis on providing murine models that are free of avoidable, undesired complications. Pre and post-operative care is as important to the success of the procedure as the surgical procedure itself. The overall goal of the core is to provide murine models of bariatric surgery using procedures that are designed to reflect those performed in humans, liver transplantation, and unique customized surgical models adapted to the needs of VDDRC members. To achieve this goal the core: 1. Provides mouse bariatric surgery models with application to basic and translational research. 2. Provides mouse models of Barrett's esophagus and liver and small bowel transplantation. 3. Provides peri-operative care to ensure that animals are healthy and free of undue stress. 4. Trains investigators in specialized surgical procedures. 5. Responds to the needs of VDDRC investigators through development of new procedures. The Core interacts closely with other VDDRC Cores, the Mouse Metabolic Phenotyping Center (MMPC), the Diabetes Research and Training Center, and the Division of Animal Care to ensure and maximize efficient use of resources and personnel and enhance interdisciplinary collaboration.