FASEB SRC on Glucose transport:Gateway to Metabolic Systems Biology

 描述(由申请人提供)： 葡萄糖进入细胞是新陈代谢和能量学的中心组成部分。葡萄糖衍生的能量用于特定的细胞功能，如生长、增殖和维持的机制，以及调节变化如何有助于心脏代谢性疾病和癌症的发展是至关重要的问题。有必要从广泛的角度探讨这些问题，在这些问题中，细胞信号、营养吸收和代谢的全身和细胞机制是整合的。在过去的几年里，研究新陈代谢驱动的慢性疾病的技术取得了重大进展，包括出现了复杂的系统生物学平台。这些发展促进了理解代谢复杂性的方法，这可能包括假设驱动的发现和数据库驱动的发现，但也需要工具来支持假设检验。面对这些日新月异的变化，拟议中的FASEB夏季会议“葡萄糖运输：新陈代谢系统生物学的门户”对于最大限度地促进小组之间的沟通、建立合作和促进该领域的进展显得尤为及时和重要。NIDDK的资助将确保这一系列会议将继续有助于我们理解代谢生理学及其与疾病病理生理学的联系，同时也是鼓励和培养该领域年轻和新兴科学家的工具。

 DESCRIPTION (provided by applicant): Glucose uptake into cells is a central component of metabolism and energetics. The mechanisms by which glucose-derived energy is used for specific cellular functions such as growth, proliferation and maintenance, and how altered regulation can contribute to development of cardiometabolic diseases and cancer are critically important questions. It is necessary to explore these questions with a broad perspective, in which whole body and cellular mechanisms of cell signaling, nutrient uptake, and metabolism are integrated. Major advances in technology for investigating metabolism-driven chronic diseases have occurred in the past years, including advent of sophisticated platforms for systems biology. These developments facilitate approaches to understanding metabolic complexity that can include hypothesis-driven and database-driven discovery, but also requiring tools to enable hypothesis testing. In the face of these rapid changes, the proposed FASEB summer conference on "Glucose Transport: Gateway to Metabolic Systems Biology" seems particularly timely and important for maximizing communication among groups, forging collaborations, and facilitating progress in the field. Funding from NIDDK will ensure that this series, among the most long-lived in FASEB conference history, will continue to contribute to our understanding of metabolic physiology and its links to disease pathophysiology, while also serving as a vehicle to encourage and nurture young and emerging scientists in the field.