Cancer Research International Training and Intervention Consortium (CRITIC)

拟议的癌症联盟重点关注两种病原学的传播和感染的干预， 两种最常见的艾滋病相关癌症的病毒因子，卡波西肉瘤相关的人类 疱疹病毒（KSHV）和人乳头瘤病毒（HPV）在坦桑尼亚。联合会的目标是 加强艾滋病恶性肿瘤研究基础设施的三个关键组成部分--病毒学、流行病学 和临床护理--通过将在这些领域具有记录优势的合作伙伴联系起来。除了获得关键的 关于艾滋病相关恶性肿瘤的数据，联盟将提供各种培训机会， 当地专门知识和转让技术。总的来说，这种伙伴关系最终将导致建立 执行高质量生物医学，行为和生物医学所需的技术和人员基础设施， 坦桑尼亚急需的预防性生物医学研究。将追求四个具体目标：1） 通过长期的分子癌症流行病学培训建立联盟的研究能力 机会，长期培训导致两个博士学位，在流行病学和分子肿瘤病毒学， 分子肿瘤病毒学硕士学位和癌症流行病学硕士学位。2)加强现有 通过在美国的短期技术培训和国内研讨会，提高癌症研究能力， 研究人员、临床医生和公共卫生人员。3)建立分子病毒学研究实验室 支持分子癌症流行病学研究的组成部分和流行病学/生物统计学核心设施 项目4)支持坦桑尼亚研究团队的发展，提高研究生产力 通过支持两个假设驱动的研究项目，在两个最流行的艾滋病相关 恶性肿瘤、KS和宫颈癌。这项拟议的计划是独特的，具有很高的影响力，因为它建立了 在撒哈拉以南非洲成功进行的Fogarty计划和NCI培训计划中， 成为一个真正的跨学科的研究和培训计划与不同的培训轨道，并与国内 坦桑尼亚和美国研究人员合作开展的研究项目，对KS进行假设驱动的研究， 宫颈癌和它们各自的病原体。

The proposed Cancer Consortium focuses on the intervention of transmission and infection by two etiologic viral agents of the two most common AIDS-associated cancers, the Kaposi's sarcoma-associated human herpesvirus (KSHV) and Human Papilloma Virus (HPV) in Tanzania. The objective of the Consortium is to enhance the three critical components of AIDS malignancies research infrastructure - virology, epidemiology and clinical care - by linking partners with documented strengths in these areas. In addition to deriving critical data on AIDS-associated malignancies, the Consortium will provide diverse training opportunities to increase local expertise and transfer technology. Overall, the partnership will ultimately lead to exchanges that build the technical and personnel infrastructure necessary to perform the high-quality biomedical, behavioral, and preventative biomedical research desperately needed in Tanzania. Four specific aims will be pursued: 1) Build the consortium's research capacity through long-term molecular cancer epidemiology training opportunities, with long-term training leading to two PhDs, in epidemiology and in molecular tumor virology, MS degrees in molecular tumor virology, and MPH degrees in cancer epidemiology. 2) Strengthen existing cancer research capacity through short term technical training in the US and in-country workshops targeting researchers, clinicians, and public health personnel. 3) Develop a molecular virology research laboratory component and epidemiology/biostatistics core facilities to support molecular cancer epidemiology research projects. 4) Support the development of Tanzanian research teams and increase the research productivity through supporting two hypothesis-driven research projects in the two most prevalent AIDS-associated malignancies, KS and cervical cancer. This proposed program is unique and of high impact because it builds onto a successful ongoing Fogarty program and NCI training program in sub-Saharan Africa, expanding it into a truly cross-disciplinary research and training program with different training tracks and with in-country research projects teaming Tanzanian and U.S. researchers to conduct hypothesis-driven research on KS, cervical cancer, and their respective etiologic agents.