GH16-006: Conducting Public Health Research in Kenya

摘要/概要 本提案由HJF医学研究国际（HJFMRI）提交，以回应 公告RFA-GH-16-006，在肯尼亚进行公共卫生研究，一项基金 疾病控制和预防中心（CDC）的机会。这样做的目的 合作协议是进行和监测流行病学，临床和实验室为基础的 研究肯尼亚的重要人类疾病。与肯尼亚医疗机构合作， 研究所（KEMRI），我们正在申请组件A，B，C，D和E。用于组分 A，全球健康保护司，我们的提案涉及，例如：监测 动物传染性人畜共患疾病，包括牲畜疾病的原因， 量化人的健康与与他们生活的动物之间的联系;以及 病原体在急性发热性疾病（AFI）中的作用，表征流行病学，包括 AFI的季节性对于组分B，我们的建议包括，例如，鉴定临床， 呼吸系统疾病住院患者的流行病学和营养特征， 风险因素，在肯尼亚西部等环境中，这可能会使孕妇进一步倾向于 流感的严重后果，特别是与流感疫苗接种有关。为 C部分，我们包括拟议的项目，如确定 患者提供伴侣治疗以减少沙眼衣原体和淋病奈瑟菌 再感染，并评估人类感染的流行率和发病率， 免疫缺陷病毒（HIV）感染。例如，对于组件D，我们考虑测量 通过检测循环阴极抗原（CCA）检测口腔液样本中的溶酶体抗原 并提出了一个抽样设计，以评估青蒿素为基础的治疗效果， 联合治疗儿童中有症状、无并发症的恶性疟原虫感染。 最后，对于组件E，例如，我们提出了一项研究，以衡量 三种不同的策略，以提高结核病病例发现率相比，标准 直接观察治疗（DOTS），在肯尼亚实施。我们每个 拟议的项目符合并有利于促进疾病预防控制中心肯尼亚的使命， 通过科学、政策和循证公共卫生方面的合作促进健康 行动合作公共卫生研究是HJFMRI的强项，我们提供我们的专业知识， 管理，以实现CDC的战略重点。

Abstract/Summary This proposal is submitted by the HJF Medical Research International (HJFMRI) in response to announcement RFA-GH-16-006, Conducting Public Health Research in Kenya, a funding opportunity from the Centers for Disease Control and Prevention (CDC). The purpose of this cooperative agreement is to conduct and monitor epidemiologic, clinical- and laboratory-based studies of important human diseases in Kenya. In collaboration with the Kenya Medical Research Institute (KEMRI), we are applying for Components A, B, C, D and E. For Component A, the Division of Global Health Protection, our proposal addresses, for example: surveillance for infectious zoonotic diseases in animals, covering causes of diseases in livestock and quantifying the linkages between the health of people and the animals with which they live; and the role of pathogens in acute febrile illness (AFI), characterizing the epidemiology, including seasonality of AFI. For Component B, our proposal covers, for example, identification of clinical, epidemiologic and nutritional characteristics of patients hospitalized with respiratory illness and risk factors, in settings like western Kenya, which may further predispose pregnant women to severe outcomes from influenza, especially in relationship to influenza vaccination. For Component C, we include proposed projects, such as determination of the effectiveness of patient delivered partner therapy in reducing Chlamydia trachomatis and Neisseria gonorrhea re-infection in conjunction with assessment of the prevalence and incidence of human immunodeficiency virus (HIV) infection. For Component D, for instance, we consider measuring schistosome antigens in oral fluid samples via detection of Circulating Cathodic Antigen (CCA) and present a sampling design to assess the therapeutic efficacy of Artemisinin-based combination therapies for symptomatic, uncomplicated P. falciparum infection among children. Finally, for Component E, for example, we propose a study to measure the effectiveness of three different strategies to increase the TB case detection rate compared to the standard approach, Directly Observed Treatment (DOTS) as implemented in Kenya. Each of our proposed projects is consistent with and beneficial to furthering CDC Kenya's mission to promote health through collaboration on science, policy and evidence-based public health actions. Collaborative public health research is HJFMRI's forte, and we offer our expertise in management to fulfill CDC strategic priorities.