Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort & Biobank

项目摘要/摘要 这项建议将继续对以人群为基础的密歇根狼疮流行病学进行纵向跟踪。 监视(里程)计划队列和生物库。首要目标是前瞻性地收集数据和 将允许与狼疮发病风险因素相关的全面调查的生物检验剂， 进展和合并症。迄今为止，基线一轮的队列访问已经完成，第一轮 后续的一轮访问正在进行中。详细的数据收集包括与以下方面相关的措施 社会人口学、健康/健康、生殖健康、身体机能、环境暴露、生活方式 因素和遗传因素。系统性红斑狼疮患者的狼疮特异性指标，包括疾病活动性指数。 案子。最先进的生物库包括血清、血浆、DNA/RNA(来自淋巴细胞亚群)、尿液、头发、 还有脚趾甲的碎片。生物库标本在适当的条件下处理和储存，以提供 进行分析的能力，包括当代免疫分析、疾病和暴露的生物标记物，以及 相关淋巴细胞亚群的DNA甲基化。Miles Cohort&Biobank的主要主题领域 旨在支持的研究包括表观遗传学、环境流行病学和肾红斑狼疮。里程队列将 从而为正在进行的和未来与全面相关的研究调查提供一个强大的平台 狼疮及其并发症的谱系。

PROJECT SUMMARY/ABSTRACT This proposal is to continue longitudinal follow-up of the population-based Michigan Lupus Epidemiology & Surveillance (MILES) Program Cohort and Biobank. The overarching goal is to prospectively collect data and biospecimens that will allow for comprehensive investigations related to risk factors for lupus onset, progression, and comorbidities. To date, the baseline round of Cohort visits has been completed, and the first follow-up round of visits is ongoing. Detailed data collection encompasses measures related to sociodemographics, health/wellness, reproductive health, physical function, environmental exposures, lifestyle factors, and genetics. Lupus-specific measures, including disease activity indices, are measured for the SLE cases. The state-of-the-art biobank includes serum, plasma, DNA/RNA (from lymphocyte subsets), urine, hair, and toenail clippings. Biobank specimens are processed and stored in appropriate conditions to provide the capacity to perform assays including contemporary immunoassays, biomarkers of disease and exposure, and DNA methylation of relevant lymphocyte subsets. Major thematic areas that the MILES Cohort & Biobank is designed to support include epigenetics, environmental epidemiology, and renal lupus. The MILES Cohort will thus serve as a robust platform for ongoing and future research investigations that are relevant to the full spectrum of lupus and its complications.