Center For Urban Responses to Environmental Stressors (CURES)

描述（由申请人提供） 位于底特律市中心的韦恩州立大学“城市应对环境压力中心”（CURES）专注于了解城市工业化环境中普遍存在的压力源（化学和非化学）如何影响人类健康。特别强调的是对环境暴露高度敏感的生命窗口和易受环境疾病威胁的脆弱人群（例如，社会经济地位低下的儿童和成人、老年人、移民、难民和第一反应者）。治愈中心的假设是，在工业化的城市环境中，如底特律，损害生活质量的疾病是由于个体的遗传和表观遗传组成，营养状况和环境压力之间的动态相互作用而发生的，其中包括慢性低水平毒物暴露以及心理社会和身体压力，重新编程关键的细胞调节网络以促进发病机制。四个以疾病为导向的研究兴趣小组作为人口和基础科学家以及社区成员的跨学科中心，他们对环境暴露在1）免疫疾病，2）代谢疾病，3）癌症和4）心理健康障碍中的作用感兴趣。跨学科/转化整合团队（TRANSIT）与社区顾问合作，采用综合的跨学科方法来解决环境健康问题。综合健康科学设施核心指导中心研究人员向转化研究过渡，并提供干细胞和人类生物标本服务。暴露特征设施核心使中心成员能够将综合的、最先进的基因组学、表观基因组学、蛋白质组学和生物信息学策略应用于环境健康科学研究。社区外展和参与核心为面临环境疾病风险的城市社区和中心成员之间的双向交流提供了机会。 CURES还赞助专注于职业和新项目开发的项目。治愈中心是一个充满活力的跨学科研究团队，致力于环境疾病预防，并在底特律市创造更清洁，更健康的生活和工作环境。

DESCRIPTION (provided by applicant) Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in 1) immune disorders, 2) metabolic disease, 3) cancer, and 4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.