Core D: Clinical and Population Sciences Core

临床和人口科学核心(核心D) 项目摘要 临床与人口科学(CPS)核心(核心D)的使命是支持临床、 通过这些具体目标在DC进行翻译和基于人口的研究：目标1：促进 招募和保留HIV感染和高危血清阴性的研究参与者的伦理和 在文化上适当的方式。目标2：提供全面、高质量的临床、流行病学和 生物统计研究服务。目标3：便利从以下地点获取生物样本和临床数据库 新的和现有的研究和网络。CPS核心被组织为提供对服务的高效访问， 标本和临床数据；协助培训；促进涉及临床、翻译和 以人口为基础的科学。CPS核心积极促进CFAR调查人员的研究， 强调多学科协作。服务侧重于满足其他方面未满足的研究 需要，包括提供有关方案的临床、生物统计学和设计方面的咨询专门知识 发展、专门的生物统计奖前和奖后支助(制定数据分析计划 资助赠款的提案、数据输入、管理、分析和传播)，文化上适当 社区高危人群和艾滋病毒感染人群的外展、流行病学研究设计和临床 对研究实施的支持。CPS核心将促进与多个现有的 NIH资助的当地多中心试验网络和DC Cohort，它们在 临床标本、患者群体以及广泛的二级数据集和标本储存库的术语 用于研究。因此，CPS核心将支持开发和实施#年的新研究 艾滋病毒/艾滋病，通过新的多学科倡议、专门培训、执行支助、分析 以及以创新方式传播研究结果，这对扩大临床和以人群为基础的研究至关重要 在许多情况下，通过CFAR在DC独一无二地提供研究和信息。

CLINICAL AND POPULATION SCIENCES CORE (CORE D) Project Summary The mission of the Clinical and Population Sciences (CPS) Core (Core D) is to support the growth of clinical, translational and population-based research in DC through these Specific Aims: Aim 1: To facilitate the recruitment and retention of HIV-infected and high-risk seronegative study participants in an ethical and culturally appropriate manner. Aim 2: To provide comprehensive and high-quality clinical, epidemiologic and biostatistical research services. Aim 3: To facilitate access to biological samples and clinical databases from new and existing studies and networks. The CPS Core is organized to provide efficient access to services, specimens and clinical data; assist with training; and promote collaborations involving clinical, translational and population-based science. The CPS Core actively facilitates research by CFAR investigators, with an emphasis on multidisciplinary collaborative efforts. Services focus on meeting otherwise unmet research needs, including provision of consultative clinical, biostatistical and design expertise surrounding protocol development, dedicated biostatistical pre-and post-award support (development of data analysis plans for proposals, data entry, management, analysis and dissemination for funded grants), culturally appropriate outreach to at-risk and HIV-infected populations in the community, epidemiologic study design and clinical support for study implementation. The CPS Core will facilitate increased engagement with the multiple existing NIH-funded multicenter trials networks locally and the DC Cohort, which provide outstanding resources in terms of clinical specimens, patient populations and extensive secondary datasets and specimen repositories for research. As a result, the CPS Core will support the development and implementation of novel research in HIV/AIDS through new multidisciplinary initiatives, specialized training, support for implementation, analysis and dissemination of findings in innovative ways that are critical to expansion of clinical and population-based research and are, in many instances, uniquely available in DC through the CFAR.