Translational Research Training in Pediatric Nephrology

 描述(由申请者提供)：加州大学洛杉矶分校大卫·格芬医学院拟议的儿科肾病T32转化研究培训计划旨在为儿科肾病和相关学科的学术研究生涯培养杰出的博士后学者(MD和/或博士)，目前全国内科科学家的数量正在下降，对改善对慢性病护理的理解和管理的需求不断扩大。在最初的5年期间，每年有4名博士后实习生，每人 对于两年或三年的任命，这一新的培训计划将满足专注于慢性肾脏疾病(CKD)各种发育问题的关键需求或研究，并将通过在基本、临床和基于人群的CKD方法的不同概念和方法的严格交叉培训，包括通过医疗服务研究和政策分析评估医疗保健系统的影响，促进跨T1-T4转化医学领域的跨学科合作目标。在过去的几十年里，在儿童肾脏疾病的诊断、治疗和管理方面取得了重大进展，这些患者的寿命总共增加了。然而，这一成功也带来了新的健康状况挑战，如心血管疾病(主要死亡原因)、肌肉骨骼问题、生长迟缓、感染和同种异体移植物丧失等，所有这些问题都从发展的角度得到了最佳解决。为了应对这些挑战，这一新项目的跨学科课程和有指导的动手研究培训涵盖了生物医学和临床科学，包括比较有效性和以患者为中心的结果研究，将35名致力于协作、基于团队的科学的高质量多学科教职员工的科学专业知识和指导经验交织在一起。新的培训计划将利用加州大学洛杉矶分校的专业培训和高级研究计划、翻译科学培训计划(原K30)以及现有的核心课程和保护时间的K12、T32和R25计划的资源，所有这些计划都旨在实现以下具体目标：(1)扩大生命和健康科学的多学科知识库，因为它涉及儿科肾脏疾病的不同方面；(2)在临床-翻译研究的智力和哲学基础方面提供教学和实验研究培训；(3)培养学员为出版物和赠款撰写科学文章的技能；(4)提供学术环境，使学术医学作为与儿科肾病密切相关的交叉研究领域的跨学科团队的成员和领导者，能够发展成功、独立的学术生涯所需的研究技能和经验；以及(5)为学员的发展提供模式研究赋权教学和指导技能，包括随着他们的职业发展向稳定的、科学独立的方向发展，他们最终复制终身CKD和共病的研究培训计划。

 DESCRIPTION (provided by applicant): The proposed Translational Research Training in Pediatric Nephrology T32 program at the David Geffen School of Medicine at UCLA is designed to prepare outstanding postdoctoral scholars (MDs and/or PhDs) for academic research careers in Pediatric Nephrology and aligned disciplines, at a time of declining numbers of physician-scientists nationwide and of expanding need for improved understanding and management of chronic disease care. During the initial 5-year period, with 4 postdoctoral trainees per year, each for a 2- or, if indicated, 3-year appointment, this new training program will fill a critical need or research focused on a diverse range of developmental issues in chronic kidney disease (CKD) and will advance the goals of interdisciplinary collaboration across the T1-T4 spectrum of translational medicine through rigorous cross- training in the different concepts and methods of basic, clinical, and population- and laboratory-based approaches to CKD, including assessment of health care system impact through health services research and policy analysis. Over the last several decades, major advances have occurred in the diagnosis, treatment, and management of kidney diseases in childhood, altogether resulting in the increased life span of such patients. This success has, however, brought new health status challenges, such as cardiovascular disease (the leading cause of death), muscle-skeletal problems, growth retardation, infections, and allograft loss, among others, all of which are optimally addressed from a developmental perspective. In response to these challenges, the interdisciplinary curriculum and mentored, hands-on research training of this new program encompass the biomedical and clinical sciences, including comparative effectiveness and patient-centered outcomes research, interweaving the scientific expertise and mentoring experience of 35 high-quality multidisciplinary faculty who are committed to collaborative, team-based science. The new training program will leverage the resources of the UCLA Specialty Training and Advanced Research Program, Training Program in Translational Science (former K30), and existing K12, T32, and R25 programs for the core curriculum and protected time, all collectively geared to achieve the following specific aims: (1) expand the multidisciplinary knowledge base of life and health sciences as it relates to different aspects of pediatric kidney diseases; (2) provide didactic and experimental research training in the intellectual and philosophical foundation of clinical-translational research; (3) develop trainees' scientific writing skills for publications ad grants; (4) provide an academic environment that enables development of the research skills and experience needed for successful, independent scientific careers in academic medicine as members and leaders of interdisciplinary teams in cross-cutting research domains germane to Pediatric Nephrology; and (5) model research-empowering teaching and mentoring skills for trainees' development, including their eventual replication of research training programs in life-span CKD and co-morbidities as their careers evolve into stable, scientific independence.