The Organizational Hub and Web Portal for the 4D Nucleome Network

 描述（由申请人提供）：最近的技术发展大大提高了我们对细胞核三维组织的理解。3D核组在调节基因表达中起着重要作用，这一点也越来越清楚。正在生成大量数据，以研究核组织（4D核组）的时间变化对正常发育和疾病过程的影响。该提案的主要目标是为4D核组创建有效的组织中心和门户网站。我们还建议开发一个有效的协调结构的4D核组活动。首先，我们将开发和组织有效的联网方法和联盟会议，以制定协议和标准。我们将制定一个框架，用于协调资助的4D核组项目。我们将组织年度财团范围内的受助人会议。我们将利用专业组织者谁曾与PI和高级会议场地阿特金森大厅在加州大学圣地亚哥分校（http：www.calit2.net）。年会期间将举办两项主要活动。其次，我们将开发一个适应性强、可扩展且用户友好的4DN门户网站。我们将建立4DN网络社区门户网站和虚拟资源库。该门户将是一个集成的、多功能的、可互操作的数据管理、检索、分析和可视化系统。我们将利用ENCODE比较浏览器（http：encode.cepbrowser.org）开发4D网络门户。此外，该门户将纳入联合体外部产生的数据，发布联合体商定的协议的电子手册，并提供关于数据清理的最新信息。第三，我们将协调和管理4DN网络机会池。资金的机会池将以100%的透明度进行分配和管理。资金的竞争性分配将由一位在管理中心和培训赠款方面具有丰富经验的专业经理协调。第四，我们将制定一项全面的培训和外联战略。拟议的单位将定期培训和更新4DN研究网络成员和合作者在几个关键领域，包括：1）新技术; 2）数据/样本收集协议; 3）数据分析方法; 4）数据提交协议; 5）数据检索方法; 6）数据质量保证/质量控制; 7）数据交换标准和数据本体; 8）不同的4DN和公共数据库的内容; 9）数据隐私和10）数据传播。

 DESCRIPTION (provided by applicant): Recent technological developments have significantly advanced our understanding of the three-dimensional organization of the nucleus. It has also become increasingly clear that the 3D nucleome plays an important role in regulating gene expression. Large cohorts of data are being generated to investigate the impact of the temporal changes of nuclear organization (the 4D nucleome) to normal development and disease processes. The primary goal of this proposal is the creation of an effective organizational hub and web portal for the 4D nucleome. We also propose to develop an effective coordination structure for the 4D nucleome activities. First, we will develop and organize effective networking methods and consortium meetings for establishing protocols and standards. We will develop a framework for coordination of the funded 4D nucleome projects. We will organize annual consortium-wide grantees meeting. We will utilize the professional organizers who have previously worked with the PIs and the premium conference venues at Atkinson Hall in UCSD (http://www.calit2.net). Two major activities will be organized during the annual meeting. Second, we will develop an adaptable, scalable, and user-friendly 4DN web portal. We will build the 4DN Network community web portal and a Virtual Resource Repository. This portal will be an integrated, versatile, and inter-operable data management, retrieval, analysis, and visualization system. We will leverage the ENCODE Comparative Browser (http://encode.cepbrowser.org) for developing the 4D network portal. In addition, the portal will incorporate data generated from outside the consortium, publish E-manuals for the consortium-agreed protocols, and provide the most up-to-date information on the data clearance. Third, we will coordinate and manage the 4DN Network Opportunity Pool. The opportunity pool of funds will be distributed and managed with 100% transparency. Competitive distribution with the funds will be coordinated by a professional manager with extensive experience in managing Center and Training Grants. Fourth, we will develop a comprehensive strategy for training and outreach. The proposed unit will aim to regularly train and update 4DN research network members and collaborators in several key areas including: 1) new technologies; 2) data/sample collection protocols; 3) data analysis methods; 4) data submission protocols; 5) data retrieval methods; 6) data QA/QC; 7) data exchange standards and data ontologies; 8) the contents of different 4DN and public databases; 9) data privacy and 10) data dissemination.