Nebraska Center for Cellular Signaling

描述（由申请人提供）：本COBRE III期申请建议继续内布拉斯加州细胞信号中心，该中心旨在加强内布拉斯加大学医学中心（UNMC）的研究。该应用程序的具体目标是：目标1：提供支持，以维持合作研究和指导新的研究人员在细胞信号领域。目标2：加强研究能力，创新，并为隶属于NCCS的调查人员提供资金支持。目标3：使NCCS从IDEA资助中毕业，成为一个自我维持的细胞信号卓越研究中心。该中心是由COBRE计划的第一阶段和第二阶段资金建立的。该中心的既定目标是：1）扩大目前对细胞信号传导的关注; 2）提高内布拉斯加州研究型大学的研究水平，特别是UNMC牙科学院，3）为有前途的年轻教师的发展做出贡献，使他们成为科学界的杰出成员，如NIH的重大资助，重要手稿的出版，参加审查小组并应邀在全国各地发言。我们以非凡的成功实现了我们的每一个目标。随着我们的基础设施到位，九开始助理教授收到投资回报率或主要ACS支持。在牙科学院招聘的四名新教师中，有三名是这九名教师。我们制定了旨在加强和维持中心的计划，包括支持合作项目，正在进行的研讨会计划，以及利用核心和专业开发团队。我们的职业发展计划的成功是通过我们的毕业生编辑委员会的任命，审查小组作为成员或主席的服务，并邀请出席研讨会。我们得到了机构的大力支持，并制定了在COBRE资金到期时维持中心的计划。PI和联合董事致力于继续我们的指导文化和成功文化。该中心的形成所产生的合作环境已经并将继续加强内布拉斯加州研究机构内的研究和研究基础设施。

DESCRIPTION (provided by applicant): This COBRE Phase III application proposes to continue The Nebraska Center for Cellular Signaling which was established to strengthen research within the University of Nebraska Medical Center (UNMC). The Specific Aims of this application are: Aim 1: Provide support to sustain collaborative research and mentoring of new investigators in the realm of cellular signaling. Aim 2: Strengthen research capabilities, innovation, and funding support for investigators affiliated with the NCCS. Aim 3: Graduate the NCCS from IDeA funding as a self-sustaining center of research excellence in cellular signaling. The Center was established with Phase I and II funding from the COBRE program. The stated objectives of the Center were 1) to expand the current focus on cellular signaling; 2) to increase the research profile of research universities in Nebraska, especially the College of Dentistry of UNMC, and 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. We have accomplished each of our goals with exceptional success. With our infrastructure in place, nine beginning Assistant Professors received ROI or major ACS support. Three of the four new faculty recruited to the College of Dentistry are among these nine. We have instituted programs designed to enhance and sustain the Center, including support for collaborative projects, ongoing seminar programs, and utilization of cores and a professional development team. The success of our career development programs is shown by appointments of our graduates to editorial boards, service on review panels as members or chairs, and invitations to present seminars. We have strong support from the institution with plans in place to sustain the Center when COBRE funding expires. The PI and co-directors are committed to continuing our culture of mentoring and our culture of success. The collaborative environment resulting from the formation of the Center has and will continue to enhance research and the research infrastructure within Nebraska's research institutions.