CDU Diversity-promoting Institutions Drug Abuse Research Development Program

描述（由申请人提供）：尽管NIDA和其他机构的戒烟努力取得了成功，但仍有数百万美国人继续吸烟。此外，我们的实验室已经发现了尼古丁代谢影响的重要结果，包括尼古丁加上高脂肪饮食（HFD）导致肝脏和肌肉脂肪变性的发现。我们还使用了一个大型数据库来显示二手烟与糖尿病和肥胖都有关联。这促使我们将查尔斯·r·德鲁医学与科学大学（CDU）促进多样性机构药物滥用研究计划（DIDARP）的主题定为“尼古丁的代谢影响：它很重要”。我们的培训主题将继续是“未来的研究团队”，这是基于NIH的路线图。我们的培训计划将重点关注所有级别的少数族裔学员，并通过解决药物滥用问题来实现长期的改变。DIDARP的研究、培训和教育项目的总体目标是提高CDU进行药物滥用研究的能力，主要关注尼古丁的代谢影响。基民盟DIDARP的具体目标是：1。增加与尼古丁代谢效应相关的高质量药物成瘾研究项目的数量，使CDU能够发展专业知识并获得初步数据，以便能够竞争NIDA P01， P50或ROI拨款；2. 通过提供有意义的教育和研究经验，继续培养代表性不足的学生和其他学员对药物滥用研究的兴趣；和3。继续加强基民盟的研究基础设施，以支持药物滥用研究。为了实现这些目标，我们将有3个相关的跨学科项目：项目一：尼古丁加剧高脂肪饮食诱导

DESCRIPTION (provided by applicant): Although smoking cessation efforts by NIDA and others have been successful, millions of Americans continue to smoke. Additionally, our laboratories have found important results on the metabolic effects of nicotine, including findings that nicotine plus a high fat diet (HFD) leads to hepatic and muscle steatosis. We have also used a large database to show that secondhand smoke is associated with both diabetes and obesity. This has led us to develop the theme of the Charles R. Drew University of Medicine and Science (CDU) Diversity-Promoting Institution Drug Abuse Research Program (DIDARP) to be "Metabolic Effects of Nicotine: it Matters." Our training theme will continue to be "Research Teams of the Future" that is based on the NIH roadmap. Our training program will focus on minority trainees at all levels and make a difference in the long run by tackling the problem of substance abuse. The overarching goal of the research, training and education programs of this DIDARP are to enhance CDU's capacity to conduct substance abuse research with a primary focus on the metabolic effects of nicotine. The specific goals of CDU DIDARP are: 1. To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or ROI grants; 2. To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and 3. To continue to enhance the research infrastructure at CDU to support substance abuse research. To achieve these goals, we will have 3 related, cross-disciplinary projects: Project 1: Nicotine exacerbates high fat diet-induced hepatic steatosis and skeletal muscle abnormalities in obese mice. Pilot Project A: Understanding the role of dopamine in binge-eating, nicotine and alcohol use: a translational PET study. Pilot Project B: The association between secondhand smoking and diabetes, obesity and other chronic diseases. Achieving these goals will eventually help reduce the health disparities as related to substance abuse.