Postdoctoral Research Training in Anesthesiology and Critical Care Medicine

 描述（由申请人提供）：麻醉学成功地使术中环境成为一个非常安全的地方，这一成就现在已被其他专业认可和效仿，但这不应掩盖这样一个事实，即关于整个围手术期经验的重要基本问题仍然没有答案。这些问题包括1）全身麻醉作用的机制，2）围手术期状态的系统生物学，3）术后谵妄和认知功能障碍的机制和预防，4）麻醉剂的潜在毒性，5）如何通过在围手术期应用最佳实践和有效沟通来提高安全性，6）如何改善可能与围手术期相关的长期结局，7）重症监护中的器官衰竭，以及8）急性和慢性疼痛的机制和治疗。然而，保持科学基础设施，将引导麻醉学进入未来需要一个训练有素和积极的医生科学家的专业谁是致力于追求重要的问题，该领域的核心。为了帮助确保麻醉学的科学稳健的未来，约翰霍普金斯大学麻醉学和重症监护医学系（ACCM）正在提交此更新申请，以继续支持麻醉学博士后研究培训。除了为培训生提供支持的关键途径外，预计该计划将继续完善约翰霍普金斯ACCM招募、培训和培养麻醉学专业下一代医生-科学家的方法。ACCM在麻醉学临床和基础研究培训方面有着悠久而富有成效的历史，本培训计划将继续建立并正式化。这一期望现在正在实现与优秀的过去和现在的受训人员支持的培训方案。当与ACCM和约翰霍普金斯大学的教师发展已经到位的相当多的资源相结合时，这个麻醉学博士后研究培训补助金将继续为培训物理学家科学家提供一个出色的机会，他们将继续为麻醉学的实践建立科学基础。

 DESCRIPTION (provided by applicant): Anesthesiology's success in making the intraoperative environment an extremely safe place, an accomplishment now recognized and emulated by other specialties, should not obscure the fact that important fundamental questions about the entire perioperative experience remain unanswered. These questions include 1) the mechanism of general anesthetic action, 2) systems biology of the perioperative state, 3) the mechanism and prevention of postoperative delirium and cognitive dysfunction, 4) potential toxicity of the anesthetics 5) how to increase safety by applying best practices and effective communication throughout the perioperative period, 6) how to improve long-term outcomes that may relate to the perioperative period, 7) organ failure in critical care, and 8) the mechanism and treatment of acute and chronic pain. However, maintaining the scientific infrastructure that will guide Anesthesiology into the future requires a core of well-trained and motivated Physician-Scientists within the specialty who are dedicated to the pursuit of problems important to the field. To help ensure a scientifically robust future for Anesthesiology, the Department of Anesthesiology and Critical Care Medicine (ACCM) at the Johns Hopkins University is submitting this renewal application to continue support of Postdoctoral Research Training in Anesthesiology. In addition to providing a critical avenue for the support of Trainees, it is anticipated that this program will continue to refine the approach whereby Johns Hopkins ACCM recruits, trains, and develops the next generation of Physician- Scientists in the specialty of Anesthesiology. ACCM has a long and productive history of clinical and basic research training in Anesthesiology, which this Training Program will continue to build upon and formalize. This expectation is now being realized with the outstanding past and current Trainees supported by the Training Program. When combined with the considerable resources already in place for faculty development within ACCM and at Johns Hopkins University, this Anesthesiology Postdoctoral Research Training grant will continue to provide an outstanding opportunity for training Physician-Scientists who will continue to build the scientific foundation for the practiceof Anesthesiology.